Cargando…

Factors associated with multidrug-resistant bacteria in healthcare-associated infections: a pediatric intensive care unit case-control study

OBJECTIVE: To investigate the prevalence of factors related to healthcare-associated infections, caused by multidrug-resistant bacteria, in a pediatric intensive care unit. METHODS: A retrospective case-control study conducted from January 1, 2007 to December 31, 2018, in São Paulo (SP), Brazil. The...

Descripción completa

Detalles Bibliográficos
Autores principales: da Silva, Barbara Barduchi Oliveira, Silva, Moacyr, de Menezes, Fernando Gatti, Troster, Eduardo Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Israelita de Ensino e Pesquisa Albert Einstein 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018062/
https://www.ncbi.nlm.nih.gov/pubmed/35476086
http://dx.doi.org/10.31744/einstein_journal/2022AO6704
_version_ 1784688925456990208
author da Silva, Barbara Barduchi Oliveira
Silva, Moacyr
de Menezes, Fernando Gatti
Troster, Eduardo Juan
author_facet da Silva, Barbara Barduchi Oliveira
Silva, Moacyr
de Menezes, Fernando Gatti
Troster, Eduardo Juan
author_sort da Silva, Barbara Barduchi Oliveira
collection PubMed
description OBJECTIVE: To investigate the prevalence of factors related to healthcare-associated infections, caused by multidrug-resistant bacteria, in a pediatric intensive care unit. METHODS: A retrospective case-control study conducted from January 1, 2007 to December 31, 2018, in São Paulo (SP), Brazil. The study was carried out at the pediatric intensive care unit of a high-complexity, tertiary care general hospital. The study included patients aged 1 month to 19 years, admitted to the pediatric intensive care unit, diagnosed as healthcare-associated infections. RESULTS: There was significant evidence of infection by multidrug-resistant bacteria associated with immunosuppressed patients (p<0.001), in whom the likelihood of multidrug-resistant bacteria infection was estimated to be nine-fold higher than among non-immunosuppressed patients (OR 8.97; 95%CI 2.69-29.94). In the analysis of multiple logistic regression model, we observed that immunosuppressed patients had an 8.5-fold higher chance of multidrug-resistant bacteria infection when compared to non-immunosuppressed patients (OR 8.48; 95%CI 2.54-28.35; p=0.001). There is evidence of association between the Case Group and presence of Gram-positive (p=0.007), coagulase-negative Staphylococcus (p<0.001), and Gram-negative (p=0.041) microorganisms. CONCLUSION: The immunocompromised-state variable is a factor related to healthcare-associated infections caused by multidrug-resistant bacteria, and the Case Group presented higher proportions of Gram-positive microorganisms and coagulase-negative Staphylococcus.
format Online
Article
Text
id pubmed-9018062
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Instituto Israelita de Ensino e Pesquisa Albert Einstein
record_format MEDLINE/PubMed
spelling pubmed-90180622022-04-22 Factors associated with multidrug-resistant bacteria in healthcare-associated infections: a pediatric intensive care unit case-control study da Silva, Barbara Barduchi Oliveira Silva, Moacyr de Menezes, Fernando Gatti Troster, Eduardo Juan Einstein (Sao Paulo) Original Article OBJECTIVE: To investigate the prevalence of factors related to healthcare-associated infections, caused by multidrug-resistant bacteria, in a pediatric intensive care unit. METHODS: A retrospective case-control study conducted from January 1, 2007 to December 31, 2018, in São Paulo (SP), Brazil. The study was carried out at the pediatric intensive care unit of a high-complexity, tertiary care general hospital. The study included patients aged 1 month to 19 years, admitted to the pediatric intensive care unit, diagnosed as healthcare-associated infections. RESULTS: There was significant evidence of infection by multidrug-resistant bacteria associated with immunosuppressed patients (p<0.001), in whom the likelihood of multidrug-resistant bacteria infection was estimated to be nine-fold higher than among non-immunosuppressed patients (OR 8.97; 95%CI 2.69-29.94). In the analysis of multiple logistic regression model, we observed that immunosuppressed patients had an 8.5-fold higher chance of multidrug-resistant bacteria infection when compared to non-immunosuppressed patients (OR 8.48; 95%CI 2.54-28.35; p=0.001). There is evidence of association between the Case Group and presence of Gram-positive (p=0.007), coagulase-negative Staphylococcus (p<0.001), and Gram-negative (p=0.041) microorganisms. CONCLUSION: The immunocompromised-state variable is a factor related to healthcare-associated infections caused by multidrug-resistant bacteria, and the Case Group presented higher proportions of Gram-positive microorganisms and coagulase-negative Staphylococcus. Instituto Israelita de Ensino e Pesquisa Albert Einstein 2022-04-13 /pmc/articles/PMC9018062/ /pubmed/35476086 http://dx.doi.org/10.31744/einstein_journal/2022AO6704 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
da Silva, Barbara Barduchi Oliveira
Silva, Moacyr
de Menezes, Fernando Gatti
Troster, Eduardo Juan
Factors associated with multidrug-resistant bacteria in healthcare-associated infections: a pediatric intensive care unit case-control study
title Factors associated with multidrug-resistant bacteria in healthcare-associated infections: a pediatric intensive care unit case-control study
title_full Factors associated with multidrug-resistant bacteria in healthcare-associated infections: a pediatric intensive care unit case-control study
title_fullStr Factors associated with multidrug-resistant bacteria in healthcare-associated infections: a pediatric intensive care unit case-control study
title_full_unstemmed Factors associated with multidrug-resistant bacteria in healthcare-associated infections: a pediatric intensive care unit case-control study
title_short Factors associated with multidrug-resistant bacteria in healthcare-associated infections: a pediatric intensive care unit case-control study
title_sort factors associated with multidrug-resistant bacteria in healthcare-associated infections: a pediatric intensive care unit case-control study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018062/
https://www.ncbi.nlm.nih.gov/pubmed/35476086
http://dx.doi.org/10.31744/einstein_journal/2022AO6704
work_keys_str_mv AT dasilvabarbarabarduchioliveira factorsassociatedwithmultidrugresistantbacteriainhealthcareassociatedinfectionsapediatricintensivecareunitcasecontrolstudy
AT silvamoacyr factorsassociatedwithmultidrugresistantbacteriainhealthcareassociatedinfectionsapediatricintensivecareunitcasecontrolstudy
AT demenezesfernandogatti factorsassociatedwithmultidrugresistantbacteriainhealthcareassociatedinfectionsapediatricintensivecareunitcasecontrolstudy
AT trostereduardojuan factorsassociatedwithmultidrugresistantbacteriainhealthcareassociatedinfectionsapediatricintensivecareunitcasecontrolstudy