Drug targeting Nsp1-ribosomal complex shows antiviral activity against SARS-CoV-2

The SARS-CoV-2 non-structural protein 1 (Nsp1) contains an N-terminal domain and C-terminal helices connected by a short linker region. The C-terminal helices of Nsp1 (Nsp1-C-ter) from SARS-CoV-2 bind in the mRNA entry channel of the 40S ribosomal subunit and blocks mRNA entry, thereby shutting down...

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Detalles Bibliográficos
Autores principales: Afsar, Mohammad, Narayan, Rohan, Akhtar, Md Noor, Das, Deepakash, Rahil, Huma, Nagaraj, Santhosh Kambaiah, Eswarappa, Sandeep M, Tripathi, Shashank, Hussain, Tanweer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018067/
https://www.ncbi.nlm.nih.gov/pubmed/35323109
http://dx.doi.org/10.7554/eLife.74877

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018067/
https://www.ncbi.nlm.nih.gov/pubmed/35323109
http://dx.doi.org/10.7554/eLife.74877

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