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Neural excursions from manifold structure explain patterns of learning during human sensorimotor adaptation
Humans vary greatly in their motor learning abilities, yet little is known about the neural mechanisms that underlie this variability. Recent neuroimaging and electrophysiological studies demonstrate that large-scale neural dynamics inhabit a low-dimensional subspace or manifold, and that learning i...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018069/ https://www.ncbi.nlm.nih.gov/pubmed/35438633 http://dx.doi.org/10.7554/eLife.74591 |
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author | Areshenkoff, Corson Gale, Daniel J Standage, Dominic Nashed, Joseph Y Flanagan, J Randall Gallivan, Jason P |
author_facet | Areshenkoff, Corson Gale, Daniel J Standage, Dominic Nashed, Joseph Y Flanagan, J Randall Gallivan, Jason P |
author_sort | Areshenkoff, Corson |
collection | PubMed |
description | Humans vary greatly in their motor learning abilities, yet little is known about the neural mechanisms that underlie this variability. Recent neuroimaging and electrophysiological studies demonstrate that large-scale neural dynamics inhabit a low-dimensional subspace or manifold, and that learning is constrained by this intrinsic manifold architecture. Here, we asked, using functional MRI, whether subject-level differences in neural excursion from manifold structure can explain differences in learning across participants. We had subjects perform a sensorimotor adaptation task in the MRI scanner on 2 consecutive days, allowing us to assess their learning performance across days, as well as continuously measure brain activity. We find that the overall neural excursion from manifold activity in both cognitive and sensorimotor brain networks is associated with differences in subjects’ patterns of learning and relearning across days. These findings suggest that off-manifold activity provides an index of the relative engagement of different neural systems during learning, and that subject differences in patterns of learning and relearning are related to reconfiguration processes occurring in cognitive and sensorimotor networks. |
format | Online Article Text |
id | pubmed-9018069 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-90180692022-04-20 Neural excursions from manifold structure explain patterns of learning during human sensorimotor adaptation Areshenkoff, Corson Gale, Daniel J Standage, Dominic Nashed, Joseph Y Flanagan, J Randall Gallivan, Jason P eLife Neuroscience Humans vary greatly in their motor learning abilities, yet little is known about the neural mechanisms that underlie this variability. Recent neuroimaging and electrophysiological studies demonstrate that large-scale neural dynamics inhabit a low-dimensional subspace or manifold, and that learning is constrained by this intrinsic manifold architecture. Here, we asked, using functional MRI, whether subject-level differences in neural excursion from manifold structure can explain differences in learning across participants. We had subjects perform a sensorimotor adaptation task in the MRI scanner on 2 consecutive days, allowing us to assess their learning performance across days, as well as continuously measure brain activity. We find that the overall neural excursion from manifold activity in both cognitive and sensorimotor brain networks is associated with differences in subjects’ patterns of learning and relearning across days. These findings suggest that off-manifold activity provides an index of the relative engagement of different neural systems during learning, and that subject differences in patterns of learning and relearning are related to reconfiguration processes occurring in cognitive and sensorimotor networks. eLife Sciences Publications, Ltd 2022-04-19 /pmc/articles/PMC9018069/ /pubmed/35438633 http://dx.doi.org/10.7554/eLife.74591 Text en © 2022, Areshenkoff et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Areshenkoff, Corson Gale, Daniel J Standage, Dominic Nashed, Joseph Y Flanagan, J Randall Gallivan, Jason P Neural excursions from manifold structure explain patterns of learning during human sensorimotor adaptation |
title | Neural excursions from manifold structure explain patterns of learning during human sensorimotor adaptation |
title_full | Neural excursions from manifold structure explain patterns of learning during human sensorimotor adaptation |
title_fullStr | Neural excursions from manifold structure explain patterns of learning during human sensorimotor adaptation |
title_full_unstemmed | Neural excursions from manifold structure explain patterns of learning during human sensorimotor adaptation |
title_short | Neural excursions from manifold structure explain patterns of learning during human sensorimotor adaptation |
title_sort | neural excursions from manifold structure explain patterns of learning during human sensorimotor adaptation |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018069/ https://www.ncbi.nlm.nih.gov/pubmed/35438633 http://dx.doi.org/10.7554/eLife.74591 |
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