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Genome-Wide Characterization of a Highly Penetrant Form of Hyperlipoprotein(a)emia Associated With Genetically Elevated Cardiovascular Risk

Lp(a) (lipoprotein [a]) is a highly atherogenic lipoprotein strongly associated with coronary artery disease (CAD). Lp(a) concentrations are chiefly determined genetically. Investigation of large pedigrees with extreme Lp(a) using modern whole-genome approaches may unravel the genetic determinants u...

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Detalles Bibliográficos
Autores principales: Coassin, Stefan, Chemello, Kevin, Khantalin, Ilya, Forer, Lukas, Döttelmayer, Patricia, Schönherr, Sebastian, Grüneis, Rebecca, Chong-Hong-Fong, Clément, Nativel, Brice, Ramin-Mangata, Stéphane, Gallo, Antonio, Roche, Mathias, Muelegger, Beatrix, Gieger, Christian, Peters, Annette, Zschocke, Johannes, Marimoutou, Catherine, Meilhac, Olivier, Lamina, Claudia, Kronenberg, Florian, Blanchard, Valentin, Lambert, Gilles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018215/
https://www.ncbi.nlm.nih.gov/pubmed/35133173
http://dx.doi.org/10.1161/CIRCGEN.121.003489