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Malignant stromal cell tumor of the spleen in a WBN/Kob rat
Primary splenic stromal tumors have rarely been reported in rodents. We report the case of a 90-week-old male WBN/Kob rat with a nodular demarcated mass in the spleen, which was kept as a non-treated animal in a long-term animal study. Histopathology revealed round to short spindle-shaped tumor cell...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Japanese Society of Toxicologic Pathology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018399/ https://www.ncbi.nlm.nih.gov/pubmed/35516839 http://dx.doi.org/10.1293/tox.2021-0067 |
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author | Terayama, Yui Matsuura, Tetsuro Ozaki, Kiyokazu |
author_facet | Terayama, Yui Matsuura, Tetsuro Ozaki, Kiyokazu |
author_sort | Terayama, Yui |
collection | PubMed |
description | Primary splenic stromal tumors have rarely been reported in rodents. We report the case of a 90-week-old male WBN/Kob rat with a nodular demarcated mass in the spleen, which was kept as a non-treated animal in a long-term animal study. Histopathology revealed round to short spindle-shaped tumor cells arranged in a solid growth pattern. Invasive growth, anisokaryosis, and high mitotic activity (46 per 10 high-power fields [2.37 mm(2)]) were observed to be multifocal, but most tumor cells showed mild nuclear pleomorphism. The pattern of silver impregnation corresponded to that of the marginal zone of the red pulp. Immunohistochemistry revealed that the tumor cells were double positive for fascin and desmin and focally positive for Iba-1 and OX-6 expression. These characteristics were similar to those observed in fibroblastic reticular cells and dendritic cells in the marginal zone of the red pulp. These findings suggest that the malignant stromal cell tumor of the spleen in this case had characteristics of both fibroblastic reticular cells and dendritic cells. |
format | Online Article Text |
id | pubmed-9018399 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Japanese Society of Toxicologic Pathology |
record_format | MEDLINE/PubMed |
spelling | pubmed-90183992022-05-04 Malignant stromal cell tumor of the spleen in a WBN/Kob rat Terayama, Yui Matsuura, Tetsuro Ozaki, Kiyokazu J Toxicol Pathol Case Report Primary splenic stromal tumors have rarely been reported in rodents. We report the case of a 90-week-old male WBN/Kob rat with a nodular demarcated mass in the spleen, which was kept as a non-treated animal in a long-term animal study. Histopathology revealed round to short spindle-shaped tumor cells arranged in a solid growth pattern. Invasive growth, anisokaryosis, and high mitotic activity (46 per 10 high-power fields [2.37 mm(2)]) were observed to be multifocal, but most tumor cells showed mild nuclear pleomorphism. The pattern of silver impregnation corresponded to that of the marginal zone of the red pulp. Immunohistochemistry revealed that the tumor cells were double positive for fascin and desmin and focally positive for Iba-1 and OX-6 expression. These characteristics were similar to those observed in fibroblastic reticular cells and dendritic cells in the marginal zone of the red pulp. These findings suggest that the malignant stromal cell tumor of the spleen in this case had characteristics of both fibroblastic reticular cells and dendritic cells. Japanese Society of Toxicologic Pathology 2022-01-01 2022-04 /pmc/articles/PMC9018399/ /pubmed/35516839 http://dx.doi.org/10.1293/tox.2021-0067 Text en ©2022 The Japanese Society of Toxicologic Pathology https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Terayama, Yui Matsuura, Tetsuro Ozaki, Kiyokazu Malignant stromal cell tumor of the spleen in a WBN/Kob rat |
title | Malignant stromal cell tumor of the spleen in a WBN/Kob rat |
title_full | Malignant stromal cell tumor of the spleen in a WBN/Kob rat |
title_fullStr | Malignant stromal cell tumor of the spleen in a WBN/Kob rat |
title_full_unstemmed | Malignant stromal cell tumor of the spleen in a WBN/Kob rat |
title_short | Malignant stromal cell tumor of the spleen in a WBN/Kob rat |
title_sort | malignant stromal cell tumor of the spleen in a wbn/kob rat |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018399/ https://www.ncbi.nlm.nih.gov/pubmed/35516839 http://dx.doi.org/10.1293/tox.2021-0067 |
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