Quantitative assessment of ventilation-perfusion relationships with gallium-68 positron emission tomography/computed tomography imaging in lung cancer patients

Pulmonary functional imaging has demonstrated potential to improve thoracic radiotherapy. The purpose of this study was twofold: 1) to quantify ventilation/perfusion relationships in lung cancer patients using a new functional imaging approach, gallium-68 ((68)Ga)-positron emission tomography/comput...

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Detalles Bibliográficos
Autores principales: Li, Zhuorui, Le Roux, Pierre-Yves, Callahan, Jason, Hardcastle, Nicholas, Hofman, Michael S., Siva, Shankar, Yamamoto, Tokihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018442/
https://www.ncbi.nlm.nih.gov/pubmed/35465222
http://dx.doi.org/10.1016/j.phro.2022.03.005
Descripción
Sumario:Pulmonary functional imaging has demonstrated potential to improve thoracic radiotherapy. The purpose of this study was twofold: 1) to quantify ventilation/perfusion relationships in lung cancer patients using a new functional imaging approach, gallium-68 ((68)Ga)-positron emission tomography/computed tomography (PET/CT); and 2) to compare ventilation/perfusion matching with diffusing capacity of the lung for carbon monoxide (D(LCO)). Voxel-wise correlations between ventilation and perfusion varied widely among 19 patients (range: 0.26–0.88). (68)Ga-PET/CT-measured percent gas exchanging lung volume was moderately correlated with D(LCO) (≤0.59). Our findings suggested that (68)Ga-PET/CT ventilation/perfusion imaging provided complementary information and a reasonable surrogate for gas exchange in lung cancer patients.

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