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MFG-E8 promotes osteogenic transdifferentiation of smooth muscle cells and vascular calcification by regulating TGF-β1 signaling

Vascular calcification occurs in arterial aging, atherosclerosis, diabetes mellitus, and chronic kidney disease. Transforming growth factor-β1 (TGF-β1) is a key modulator driving the osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs), leading to vascular calcification. We hypoth...

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Detalles Bibliográficos
Autores principales:	Chiang, Hou-Yu, Chu, Pao-Hsien, Chen, Shao-Chi, Lee, Ting-Hein
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018696/ https://www.ncbi.nlm.nih.gov/pubmed/35440618 http://dx.doi.org/10.1038/s42003-022-03313-z

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