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Gut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice
Calorie restriction (CR) and fasting are common approaches to weight reduction, but the maintenance is difficult after resuming food consumption. Meanwhile, the gut microbiome associated with energy harvest alters dramatically in response to nutrient deprivation. Here, we reported that CR and high-f...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018700/ https://www.ncbi.nlm.nih.gov/pubmed/35440584 http://dx.doi.org/10.1038/s41467-022-29589-7 |
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author | Li, Mengci Wang, Shouli Li, Yitao Zhao, Mingliang Kuang, Junliang Liang, Dandan Wang, Jieyi Wei, Meilin Rajani, Cynthia Ma, Xinran Tang, Yajun Ren, Zhenxing Chen, Tianlu Zhao, Aihua Hu, Cheng Shen, Chengxing Jia, Weiping Liu, Ping Zheng, Xiaojiao Jia, Wei |
author_facet | Li, Mengci Wang, Shouli Li, Yitao Zhao, Mingliang Kuang, Junliang Liang, Dandan Wang, Jieyi Wei, Meilin Rajani, Cynthia Ma, Xinran Tang, Yajun Ren, Zhenxing Chen, Tianlu Zhao, Aihua Hu, Cheng Shen, Chengxing Jia, Weiping Liu, Ping Zheng, Xiaojiao Jia, Wei |
author_sort | Li, Mengci |
collection | PubMed |
description | Calorie restriction (CR) and fasting are common approaches to weight reduction, but the maintenance is difficult after resuming food consumption. Meanwhile, the gut microbiome associated with energy harvest alters dramatically in response to nutrient deprivation. Here, we reported that CR and high-fat diet (HFD) both remodeled the gut microbiota with similar microbial composition, Parabacteroides distasonis was most significantly decreased after CR or HFD. CR altered microbiota and reprogramed metabolism, resulting in a distinct serum bile acid profile characterized by depleting the proportion of non-12α-hydroxylated bile acids, ursodeoxycholic acid and lithocholic acid. Downregulation of UCP1 expression in brown adipose tissue and decreased serum GLP-1 were observed in the weight-rebound mice. Moreover, treatment with Parabacteroides distasonis or non-12α-hydroxylated bile acids ameliorated weight regain via increased thermogenesis. Our results highlighted the gut microbiota-bile acid crosstalk in rebound weight gain and Parabacteroides distasonis as a potential probiotic to prevent rapid post-CR weight gain. |
format | Online Article Text |
id | pubmed-9018700 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-90187002022-04-28 Gut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice Li, Mengci Wang, Shouli Li, Yitao Zhao, Mingliang Kuang, Junliang Liang, Dandan Wang, Jieyi Wei, Meilin Rajani, Cynthia Ma, Xinran Tang, Yajun Ren, Zhenxing Chen, Tianlu Zhao, Aihua Hu, Cheng Shen, Chengxing Jia, Weiping Liu, Ping Zheng, Xiaojiao Jia, Wei Nat Commun Article Calorie restriction (CR) and fasting are common approaches to weight reduction, but the maintenance is difficult after resuming food consumption. Meanwhile, the gut microbiome associated with energy harvest alters dramatically in response to nutrient deprivation. Here, we reported that CR and high-fat diet (HFD) both remodeled the gut microbiota with similar microbial composition, Parabacteroides distasonis was most significantly decreased after CR or HFD. CR altered microbiota and reprogramed metabolism, resulting in a distinct serum bile acid profile characterized by depleting the proportion of non-12α-hydroxylated bile acids, ursodeoxycholic acid and lithocholic acid. Downregulation of UCP1 expression in brown adipose tissue and decreased serum GLP-1 were observed in the weight-rebound mice. Moreover, treatment with Parabacteroides distasonis or non-12α-hydroxylated bile acids ameliorated weight regain via increased thermogenesis. Our results highlighted the gut microbiota-bile acid crosstalk in rebound weight gain and Parabacteroides distasonis as a potential probiotic to prevent rapid post-CR weight gain. Nature Publishing Group UK 2022-04-19 /pmc/articles/PMC9018700/ /pubmed/35440584 http://dx.doi.org/10.1038/s41467-022-29589-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Li, Mengci Wang, Shouli Li, Yitao Zhao, Mingliang Kuang, Junliang Liang, Dandan Wang, Jieyi Wei, Meilin Rajani, Cynthia Ma, Xinran Tang, Yajun Ren, Zhenxing Chen, Tianlu Zhao, Aihua Hu, Cheng Shen, Chengxing Jia, Weiping Liu, Ping Zheng, Xiaojiao Jia, Wei Gut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice |
title | Gut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice |
title_full | Gut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice |
title_fullStr | Gut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice |
title_full_unstemmed | Gut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice |
title_short | Gut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice |
title_sort | gut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018700/ https://www.ncbi.nlm.nih.gov/pubmed/35440584 http://dx.doi.org/10.1038/s41467-022-29589-7 |
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