AKT mutant allele-specific activation dictates pharmacologic sensitivities

AKT- a key molecular regulator of PI-3K signaling pathway, is somatically mutated in diverse solid cancer types, and aberrant AKT activation promotes altered cancer cell growth, survival, and metabolism(1–8). The most common of AKT mutations (AKT1 E17K) sensitizes affected solid tumors to AKT inhibi...

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Detalles Bibliográficos
Autores principales: Shrestha Bhattarai, Tripti, Shamu, Tambudzai, Gorelick, Alexander N., Chang, Matthew T., Chakravarty, Debyani, Gavrila, Elena I., Donoghue, Mark T. A., Gao, JianJong, Patel, Swati, Gao, Sizhi Paul, Reynolds, Margaret H., Phillips, Sarah M., Soumerai, Tara, Abida, Wassim, Hyman, David M., Schram, Alison M., Solit, David B., Smyth, Lillian M., Taylor, Barry S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018718/
https://www.ncbi.nlm.nih.gov/pubmed/35440569
http://dx.doi.org/10.1038/s41467-022-29638-1

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