WT-PE: Prime editing with nuclease wild-type Cas9 enables versatile large-scale genome editing

Large scale genomic aberrations including duplication, deletion, translocation, and other structural changes are the cause of a subtype of hereditary genetic disorders and contribute to onset or progress of cancer. The current prime editor, PE2, consisting of Cas9-nickase and reverse transcriptase e...

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Detalles Bibliográficos
Autores principales: Tao, Rui, Wang, Yanhong, Hu, Yun, Jiao, Yaoge, Zhou, Lifang, Jiang, Lurong, Li, Li, He, Xingyu, Li, Min, Yu, Yamei, Chen, Qiang, Yao, Shaohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018734/
https://www.ncbi.nlm.nih.gov/pubmed/35440051
http://dx.doi.org/10.1038/s41392-022-00936-w

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