Cargando…

Leukemia inhibitory factor drives glucose metabolic reprogramming to promote breast tumorigenesis

LIF, a multifunctional cytokine, is frequently overexpressed in many types of solid tumors, including breast cancer, and plays an important role in promoting tumorigenesis. Currently, how LIF promotes tumorigenesis is not well-understood. Metabolic reprogramming is a hallmark of cancer cells and a k...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yue, Xuetian, Wang, Jianming, Chang, Chun-yuan, Liu, Juan, Yang, Xue, Zhou, Fan, Qiu, Xia, Bhatt, Vrushank, Guo, Jessie Yanxiang, Su, Xiaoyang, Zhang, Lanjing, Feng, Zhaohui, Hu, Wenwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018736/ https://www.ncbi.nlm.nih.gov/pubmed/35440095 http://dx.doi.org/10.1038/s41419-022-04820-x

Ejemplares similares

Autophagy modulates lipid metabolism to maintain metabolic flexibility for Lkb1-deficient Kras-driven lung tumorigenesis
por: Bhatt, Vrushank, et al.
Publicado: (2019)

Leukemia inhibitory factor promotes EMT through STAT3-dependent miR-21 induction
por: Yue, Xuetian, et al.
Publicado: (2015)

A novel mutant p53 binding partner BAG5 stabilizes mutant p53 and promotes mutant p53 GOFs in tumorigenesis
por: Yue, Xuetian, et al.
Publicado: (2016)

Autophagy compensates for Lkb1 loss to maintain adult mice homeostasis and survival
por: Khayati, Khoosheh, et al.
Publicado: (2020)

The TRPM7 channel reprograms cellular glycolysis to drive tumorigenesis and angiogenesis
por: Wu, Wanzhou, et al.
Publicado: (2023)

BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function
por: Yue, Xuetian, et al.
Publicado: (2015)

Ym155 localizes to the mitochondria leading to mitochondria dysfunction and activation of AMPK that inhibits BMP signaling in lung cancer cells
por: Mondal, Arindam, et al.
Publicado: (2022)

LIF promotes tumorigenesis and metastasis of breast cancer through the AKT-mTOR pathway
por: Li, Xiaoyan, et al.
Publicado: (2014)

Inhibition of autophagy and MEK promotes ferroptosis in Lkb1-deficient Kras-driven lung tumors
por: Bhatt, Vrushank, et al.
Publicado: (2023)

microRNA-1827 represses MDM2 to positively regulate tumor suppressor p53 and suppress tumorigenesis
por: Zhang, Cen, et al.
Publicado: (2016)

Tumor suppressor p53 regulates intestinal type 2 immunity
por: Chang, Chun-Yuan, et al.
Publicado: (2021)

Fusobacterium nucleatum-triggered purine metabolic reprogramming drives tumorigenesis in head and neck carcinoma
por: Li, Feiran, et al.
Publicado: (2023)

CPT1A and fatty acid β-oxidation are essential for tumor cell growth and survival in hormone receptor-positive breast cancer
por: Jariwala, Nidhi, et al.
Publicado: (2021)

A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models
por: Zhao, Yuhan, et al.
Publicado: (2018)

TBC1D8 Amplification Drives Tumorigenesis through Metabolism Reprogramming in Ovarian Cancer
por: Chen, Min, et al.
Publicado: (2019)

Mutant GNAS drives pancreatic tumorigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism
por: Patra, Krushna C., et al.
Publicado: (2018)

Ecdysoneless Overexpression Drives Mammary Tumorigenesis through Upregulation of C-MYC and Glucose Metabolism
por: Mohapatra, Bhopal C., et al.
Publicado: (2022)

p53 connects tumorigenesis and reprogramming to pluripotency
por: Tapia, Natalia, et al.
Publicado: (2010)

G6PD Maintains Redox Homeostasis and Biosynthesis in LKB1-Deficient KRAS-Driven Lung Cancer
por: Lan, Taijin, et al.
Publicado: (2023)

Clonal Extinction Drives Tumorigenesis
por: Amaro, Adriana, et al.
Publicado: (2023)

Metabolic reprogramming: a bridge between aging and tumorigenesis
por: Drapela, Stanislav, et al.
Publicado: (2022)

Superenhancer reprogramming drives a B-cell–epithelial transition and high-risk leukemia
por: Hu, Yeguang, et al.
Publicado: (2016)

SOX4-SMARCA4 complex promotes glycolysis-dependent TNBC cell growth through transcriptional regulation of Hexokinase 2
por: Khanna, Pooja, et al.
Publicado: (2023)

An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis
por: Smith, Harvey W., et al.
Publicado: (2019)

An Activating Mutation of the NSD2 Histone Methyltransferase Drives Oncogenic Reprogramming in Acute Lymphocytic Leukemia
por: Swaroop, Alok, et al.
Publicado: (2018)

The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis
por: Pomerantz, Mark M., et al.
Publicado: (2015)

Cell Reprogramming in Tumorigenesis and Its Therapeutic Implications for Breast Cancer
por: Chu, Pei-Yi, et al.
Publicado: (2019)

The Dynamic Epigenetic Landscape of the Retina During Development, Reprogramming, and Tumorigenesis
por: Aldiri, Issam, et al.
Publicado: (2017)

EBV Infection and Its Regulated Metabolic Reprogramming in Nasopharyngeal Tumorigenesis
por: Yang, Tingting, et al.
Publicado: (2022)

Serine Metabolic Reprogramming in Tumorigenesis, Tumor Immunity, and Clinical Treatment
por: Shunxi, Wang, et al.
Publicado: (2023)

LIF is essential for ISC function and protects against radiation-induced gastrointestinal syndrome
por: Wang, Huaying, et al.
Publicado: (2020)

TGFB1 Induces Fetal Reprogramming and Enhances Intestinal Regeneration
por: Chen, Lei, et al.
Publicado: (2023)

Targeting histone methylation to reprogram the transcriptional state that drives survival of drug-tolerant myeloid leukemia persisters
por: van Gils, Noortje, et al.
Publicado: (2022)

Tumor suppressor PALB2 maintains redox and mitochondrial homeostasis in the brain and cooperates with ATG7/autophagy to suppress neurodegeneration
por: Huo, Yanying, et al.
Publicado: (2022)

Regulation of tumorigenesis in oral epithelial cells by defined reprogramming factors Oct4 and Sox2
por: Cai, Jinghua, et al.
Publicado: (2016)

MFN1-dependent alteration of mitochondrial dynamics drives hepatocellular carcinoma metastasis by glucose metabolic reprogramming
por: Zhang, Ze, et al.
Publicado: (2019)

EBV epitranscriptome reprogramming by METTL14 is critical for viral-associated tumorigenesis
por: Lang, Fengchao, et al.
Publicado: (2019)

Common Telomere Changes during In Vivo Reprogramming and Early Stages of Tumorigenesis
por: Marión, Rosa M., et al.
Publicado: (2017)

Monocytes reprogrammed by tumor microparticle vaccine inhibit tumorigenesis and tumor development
por: Sun, Weiwei, et al.
Publicado: (2023)

Glycogen overload transforms the liver: Accumulated glycogen drives liver tumorigenesis
por: Li, Peiyi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_fh43oblg9ik1u5q56fj3t2j33e