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A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma
Infections remain a common complication in patients with multiple myeloma (MM) and are associated with morbidity and mortality. A risk score to predict the probability of early severe infection could help to identify the patients that would benefit from preventive measures. We undertook a post hoc a...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018751/ https://www.ncbi.nlm.nih.gov/pubmed/35440057 http://dx.doi.org/10.1038/s41408-022-00652-2 |
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author | Encinas, Cristina Hernandez-Rivas, José-Ángel Oriol, Albert Rosiñol, Laura Blanchard, María-Jesús Bellón, José-María García-Sanz, Ramón de la Rubia, Javier de la Guía, Ana López Jímenez-Ubieto, Ana Jarque, Isidro Iñigo, Belén Dourdil, Victoria de Arriba, Felipe Pérez-Ávila, Clara Cuéllar Gonzalez, Yolanda Hernández, Miguel-Teodoro Bargay, Joan Granell, Miguel Rodríguez-Otero, Paula Silvent, Maialen Cabrera, Carmen Rios, Rafael Alegre, Adrián Gironella, Mercedes Gonzalez, Marta-Sonia Sureda, Anna Sampol, Antonia Ocio, Enrique M. Krsnik, Isabel García, Antonio García-Mateo, Aránzazu Soler, Joan-Alfons Martín, Jesús Arguiñano, José-María Mateos, María-Victoria Bladé, Joan San-Miguel, Jesús F. Lahuerta, Juan-José Martínez-López, Joaquín |
author_facet | Encinas, Cristina Hernandez-Rivas, José-Ángel Oriol, Albert Rosiñol, Laura Blanchard, María-Jesús Bellón, José-María García-Sanz, Ramón de la Rubia, Javier de la Guía, Ana López Jímenez-Ubieto, Ana Jarque, Isidro Iñigo, Belén Dourdil, Victoria de Arriba, Felipe Pérez-Ávila, Clara Cuéllar Gonzalez, Yolanda Hernández, Miguel-Teodoro Bargay, Joan Granell, Miguel Rodríguez-Otero, Paula Silvent, Maialen Cabrera, Carmen Rios, Rafael Alegre, Adrián Gironella, Mercedes Gonzalez, Marta-Sonia Sureda, Anna Sampol, Antonia Ocio, Enrique M. Krsnik, Isabel García, Antonio García-Mateo, Aránzazu Soler, Joan-Alfons Martín, Jesús Arguiñano, José-María Mateos, María-Victoria Bladé, Joan San-Miguel, Jesús F. Lahuerta, Juan-José Martínez-López, Joaquín |
author_sort | Encinas, Cristina |
collection | PubMed |
description | Infections remain a common complication in patients with multiple myeloma (MM) and are associated with morbidity and mortality. A risk score to predict the probability of early severe infection could help to identify the patients that would benefit from preventive measures. We undertook a post hoc analysis of infections in four clinical trials from the Spanish Myeloma Group, involving a total of 1347 patients (847 transplant candidates). Regarding the GEM2010 > 65 trial, antibiotic prophylaxis was mandatory, so we excluded it from the final analysis. The incidence of severe infection episodes within the first 6 months was 13.8%, and majority of the patients experiencing the first episode before 4 months (11.1%). 1.2% of patients died because of infections within the first 6 months (1% before 4 months). Variables associated with increased risk of severe infection in the first 4 months included serum albumin ≤30 g/L, ECOG > 1, male sex, and non-IgA type MM. A simple risk score with these variables facilitated the identification of three risk groups with different probabilities of severe infection within the first 4 months: low-risk (score 0–2) 8.2%; intermediate-risk (score 3) 19.2%; and high-risk (score 4) 28.3%. Patients with intermediate/high risk could be candidates for prophylactic antibiotic therapies. |
format | Online Article Text |
id | pubmed-9018751 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-90187512022-04-28 A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma Encinas, Cristina Hernandez-Rivas, José-Ángel Oriol, Albert Rosiñol, Laura Blanchard, María-Jesús Bellón, José-María García-Sanz, Ramón de la Rubia, Javier de la Guía, Ana López Jímenez-Ubieto, Ana Jarque, Isidro Iñigo, Belén Dourdil, Victoria de Arriba, Felipe Pérez-Ávila, Clara Cuéllar Gonzalez, Yolanda Hernández, Miguel-Teodoro Bargay, Joan Granell, Miguel Rodríguez-Otero, Paula Silvent, Maialen Cabrera, Carmen Rios, Rafael Alegre, Adrián Gironella, Mercedes Gonzalez, Marta-Sonia Sureda, Anna Sampol, Antonia Ocio, Enrique M. Krsnik, Isabel García, Antonio García-Mateo, Aránzazu Soler, Joan-Alfons Martín, Jesús Arguiñano, José-María Mateos, María-Victoria Bladé, Joan San-Miguel, Jesús F. Lahuerta, Juan-José Martínez-López, Joaquín Blood Cancer J Article Infections remain a common complication in patients with multiple myeloma (MM) and are associated with morbidity and mortality. A risk score to predict the probability of early severe infection could help to identify the patients that would benefit from preventive measures. We undertook a post hoc analysis of infections in four clinical trials from the Spanish Myeloma Group, involving a total of 1347 patients (847 transplant candidates). Regarding the GEM2010 > 65 trial, antibiotic prophylaxis was mandatory, so we excluded it from the final analysis. The incidence of severe infection episodes within the first 6 months was 13.8%, and majority of the patients experiencing the first episode before 4 months (11.1%). 1.2% of patients died because of infections within the first 6 months (1% before 4 months). Variables associated with increased risk of severe infection in the first 4 months included serum albumin ≤30 g/L, ECOG > 1, male sex, and non-IgA type MM. A simple risk score with these variables facilitated the identification of three risk groups with different probabilities of severe infection within the first 4 months: low-risk (score 0–2) 8.2%; intermediate-risk (score 3) 19.2%; and high-risk (score 4) 28.3%. Patients with intermediate/high risk could be candidates for prophylactic antibiotic therapies. Nature Publishing Group UK 2022-04-19 /pmc/articles/PMC9018751/ /pubmed/35440057 http://dx.doi.org/10.1038/s41408-022-00652-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Encinas, Cristina Hernandez-Rivas, José-Ángel Oriol, Albert Rosiñol, Laura Blanchard, María-Jesús Bellón, José-María García-Sanz, Ramón de la Rubia, Javier de la Guía, Ana López Jímenez-Ubieto, Ana Jarque, Isidro Iñigo, Belén Dourdil, Victoria de Arriba, Felipe Pérez-Ávila, Clara Cuéllar Gonzalez, Yolanda Hernández, Miguel-Teodoro Bargay, Joan Granell, Miguel Rodríguez-Otero, Paula Silvent, Maialen Cabrera, Carmen Rios, Rafael Alegre, Adrián Gironella, Mercedes Gonzalez, Marta-Sonia Sureda, Anna Sampol, Antonia Ocio, Enrique M. Krsnik, Isabel García, Antonio García-Mateo, Aránzazu Soler, Joan-Alfons Martín, Jesús Arguiñano, José-María Mateos, María-Victoria Bladé, Joan San-Miguel, Jesús F. Lahuerta, Juan-José Martínez-López, Joaquín A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma |
title | A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma |
title_full | A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma |
title_fullStr | A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma |
title_full_unstemmed | A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma |
title_short | A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma |
title_sort | simple score to predict early severe infections in patients with newly diagnosed multiple myeloma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018751/ https://www.ncbi.nlm.nih.gov/pubmed/35440057 http://dx.doi.org/10.1038/s41408-022-00652-2 |
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simplescoretopredictearlysevereinfectionsinpatientswithnewlydiagnosedmultiplemyeloma |