Chemotherapy-induced COX-2 upregulation by cancer cells defines their inflammatory properties and limits the efficacy of chemoimmunotherapy combinations

Cytotoxic therapies, besides directly inducing cancer cell death, can stimulate immune-dependent tumor growth control or paradoxically accelerate tumor progression. The underlying mechanisms dictating these opposing outcomes are poorly defined. Here, we show that cytotoxic therapy acutely upregulate...

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Detalles Bibliográficos
Autores principales: Bell, Charlotte R., Pelly, Victoria S., Moeini, Agrin, Chiang, Shih-Chieh, Flanagan, Eimear, Bromley, Christian P., Clark, Christopher, Earnshaw, Charles H., Koufaki, Maria A., Bonavita, Eduardo, Zelenay, Santiago
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018752/
https://www.ncbi.nlm.nih.gov/pubmed/35440553
http://dx.doi.org/10.1038/s41467-022-29606-9

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