Chimeric bacteriocin S5-PmnH engineered by domain swapping efficiently controls Pseudomonas aeruginosa infection in murine keratitis and lung models

Rampant rise of multidrug resistant strains among Gram-negative bacteria has necessitated investigation of alternative antimicrobial agents with novel modes of action including antimicrobial proteins such as bacteriocins. The main hurdle in the clinical development of bacteriocin biologics is their...

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Detalles Bibliográficos
Autores principales: Paškevičius, Šarūnas, Dapkutė, Viktorija, Misiūnas, Audrius, Balzaris, Modestas, Thommes, Pia, Sattar, Abdul, Gleba, Yuri, Ražanskienė, Aušra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018753/
https://www.ncbi.nlm.nih.gov/pubmed/35440606
http://dx.doi.org/10.1038/s41598-022-09865-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018753/
https://www.ncbi.nlm.nih.gov/pubmed/35440606
http://dx.doi.org/10.1038/s41598-022-09865-8

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