Silencing of STE20-type kinase STK25 in human aortic endothelial and smooth muscle cells is atheroprotective

Recent studies highlight the importance of lipotoxic damage in aortic cells as the major pathogenetic contributor to atherosclerotic disease. Since the STE20-type kinase STK25 has been shown to exacerbate ectopic lipid storage and associated cell injury in several metabolic organs, we here investiga...

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Detalles Bibliográficos
Autores principales: Cansby, Emmelie, Kumari, Sima, Caputo, Mara, Xia, Ying, Porosk, Rando, Robinson, Jonathan, Wang, Hao, Olsson, Britt-Marie, Vallin, Josefine, Grantham, Julie, Soomets, Ursel, Svensson, L. Thomas, Sihlbom, Carina, Marschall, Hanns-Ulrich, Edsfeldt, Andreas, Goncalves, Isabel, Mahlapuu, Margit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018782/
https://www.ncbi.nlm.nih.gov/pubmed/35440683
http://dx.doi.org/10.1038/s42003-022-03309-9

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