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Environmental induced transgenerational inheritance impacts systems epigenetics in disease etiology

Environmental toxicants have been shown to promote the epigenetic transgenerational inheritance of disease through exposure specific epigenetic alterations in the germline. The current study examines the actions of hydrocarbon jet fuel, dioxin, pesticides (permethrin and methoxychlor), plastics, and...

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Autores principales: Beck, Daniel, Nilsson, Eric E., Ben Maamar, Millissia, Skinner, Michael K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018793/
https://www.ncbi.nlm.nih.gov/pubmed/35440735
http://dx.doi.org/10.1038/s41598-022-09336-0
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author Beck, Daniel
Nilsson, Eric E.
Ben Maamar, Millissia
Skinner, Michael K.
author_facet Beck, Daniel
Nilsson, Eric E.
Ben Maamar, Millissia
Skinner, Michael K.
author_sort Beck, Daniel
collection PubMed
description Environmental toxicants have been shown to promote the epigenetic transgenerational inheritance of disease through exposure specific epigenetic alterations in the germline. The current study examines the actions of hydrocarbon jet fuel, dioxin, pesticides (permethrin and methoxychlor), plastics, and herbicides (glyphosate and atrazine) in the promotion of transgenerational disease in the great grand-offspring rats that correlates with specific disease associated differential DNA methylation regions (DMRs). The transgenerational disease observed was similar for all exposures and includes pathologies of the kidney, prostate, and testis, pubertal abnormalities, and obesity. The disease specific DMRs in sperm were exposure specific for each pathology with negligible overlap. Therefore, for each disease the DMRs and associated genes were distinct for each exposure generational lineage. Observations suggest a large number of DMRs and associated genes are involved in a specific pathology, and various environmental exposures influence unique subsets of DMRs and genes to promote the transgenerational developmental origins of disease susceptibility later in life. A novel multiscale systems biology basis of disease etiology is proposed involving an integration of environmental epigenetics, genetics and generational toxicology.
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spelling pubmed-90187932022-04-21 Environmental induced transgenerational inheritance impacts systems epigenetics in disease etiology Beck, Daniel Nilsson, Eric E. Ben Maamar, Millissia Skinner, Michael K. Sci Rep Article Environmental toxicants have been shown to promote the epigenetic transgenerational inheritance of disease through exposure specific epigenetic alterations in the germline. The current study examines the actions of hydrocarbon jet fuel, dioxin, pesticides (permethrin and methoxychlor), plastics, and herbicides (glyphosate and atrazine) in the promotion of transgenerational disease in the great grand-offspring rats that correlates with specific disease associated differential DNA methylation regions (DMRs). The transgenerational disease observed was similar for all exposures and includes pathologies of the kidney, prostate, and testis, pubertal abnormalities, and obesity. The disease specific DMRs in sperm were exposure specific for each pathology with negligible overlap. Therefore, for each disease the DMRs and associated genes were distinct for each exposure generational lineage. Observations suggest a large number of DMRs and associated genes are involved in a specific pathology, and various environmental exposures influence unique subsets of DMRs and genes to promote the transgenerational developmental origins of disease susceptibility later in life. A novel multiscale systems biology basis of disease etiology is proposed involving an integration of environmental epigenetics, genetics and generational toxicology. Nature Publishing Group UK 2022-04-19 /pmc/articles/PMC9018793/ /pubmed/35440735 http://dx.doi.org/10.1038/s41598-022-09336-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Beck, Daniel
Nilsson, Eric E.
Ben Maamar, Millissia
Skinner, Michael K.
Environmental induced transgenerational inheritance impacts systems epigenetics in disease etiology
title Environmental induced transgenerational inheritance impacts systems epigenetics in disease etiology
title_full Environmental induced transgenerational inheritance impacts systems epigenetics in disease etiology
title_fullStr Environmental induced transgenerational inheritance impacts systems epigenetics in disease etiology
title_full_unstemmed Environmental induced transgenerational inheritance impacts systems epigenetics in disease etiology
title_short Environmental induced transgenerational inheritance impacts systems epigenetics in disease etiology
title_sort environmental induced transgenerational inheritance impacts systems epigenetics in disease etiology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018793/
https://www.ncbi.nlm.nih.gov/pubmed/35440735
http://dx.doi.org/10.1038/s41598-022-09336-0
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