Heterozygous variants in GATA2 contribute to DCML deficiency in mice by disrupting tandem protein binding

Accumulating lines of clinical evidence support the emerging hypothesis that loss-of-function mutations of GATA2 cause inherited hematopoietic diseases, including Emberger syndrome; dendritic cell, monocyte B and NK lymphoid (DCML) deficiency; and MonoMAC syndrome. Here, we show that mice heterozygo...

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Detalles Bibliográficos
Autores principales: Hasegawa, Atsushi, Hayasaka, Yuki, Morita, Masanobu, Takenaka, Yuta, Hosaka, Yuna, Hirano, Ikuo, Yamamoto, Masayuki, Shimizu, Ritsuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018821/
https://www.ncbi.nlm.nih.gov/pubmed/35440757
http://dx.doi.org/10.1038/s42003-022-03316-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018821/
https://www.ncbi.nlm.nih.gov/pubmed/35440757
http://dx.doi.org/10.1038/s42003-022-03316-w

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