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The association between hypomagnesemia and poor glycaemic control in type 1 diabetes is limited to insulin resistant individuals
In a cohort of adults with type 1 diabetes, we examined the prevalence of hypomagnesemia and the correlation of serum magnesium levels with metabolic determinants, such as glycaemic control (as HbA(1c)), inflammatory markers and circulating cytokines. Furthermore, we assessed if a surrogate for insu...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018833/ https://www.ncbi.nlm.nih.gov/pubmed/35440685 http://dx.doi.org/10.1038/s41598-022-10436-0 |
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author | Oost, Lynette J. van Heck, Julia I. P. Tack, Cees J. de Baaij, Jeroen H. F. |
author_facet | Oost, Lynette J. van Heck, Julia I. P. Tack, Cees J. de Baaij, Jeroen H. F. |
author_sort | Oost, Lynette J. |
collection | PubMed |
description | In a cohort of adults with type 1 diabetes, we examined the prevalence of hypomagnesemia and the correlation of serum magnesium levels with metabolic determinants, such as glycaemic control (as HbA(1c)), inflammatory markers and circulating cytokines. Furthermore, we assessed if a surrogate for insulin resistance is essential for the possible association of serum magnesium with metabolic determinants. Individuals with type 1 diabetes, aged above 18 years, were included and clinical characteristics were obtained from questionnaires and clinical records. In venous blood samples we measured cytokines and adipose-tissue specific secretion proteins. Serum magnesium concentrations were measured and correlated with clinical data and laboratory measurements using univariate and multivariate regression models. Hierarchical multiple regression of serum magnesium with insulin resistance was adjusted for diabetes and potential magnesium confounders. The prevalence of hypomagnesemia (serum magnesium levels < 0.7 mmol/L) was 2.9% in a cohort consisting of 241 individuals with type 1 diabetes. The magnesium concentration in the cohort was not associated with HbA(1c) (r = − 0.12, P-value = 0.068) nor with any inflammatory marker or adipokine. However, insulin dose (IU/kg), a surrogate measure of resistance in type 1 diabetes, moderated the association of serum magnesium (mmol/L) with HbA(1c) (mmol/mol) with a B coefficient of − 71.91 (95% CI: − 119.11; -24.71), P-value = 0.003) and Log(10) high-sensitivity C-reactive protein (Log(10) mg/L) − 2.09 (95% CI: − 3.70; − 0.48), P-value = 0.011). The association of low serum magnesium levels with glycaemic control (HbA(1c)) and high-sensitivity C-reactive protein in individuals with type 1 diabetes is limited to subjects using a high insulin dose and suggests that insulin resistance, a type 2 diabetes feature, is a prerequisite for hypomagnesemia. |
format | Online Article Text |
id | pubmed-9018833 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-90188332022-04-21 The association between hypomagnesemia and poor glycaemic control in type 1 diabetes is limited to insulin resistant individuals Oost, Lynette J. van Heck, Julia I. P. Tack, Cees J. de Baaij, Jeroen H. F. Sci Rep Article In a cohort of adults with type 1 diabetes, we examined the prevalence of hypomagnesemia and the correlation of serum magnesium levels with metabolic determinants, such as glycaemic control (as HbA(1c)), inflammatory markers and circulating cytokines. Furthermore, we assessed if a surrogate for insulin resistance is essential for the possible association of serum magnesium with metabolic determinants. Individuals with type 1 diabetes, aged above 18 years, were included and clinical characteristics were obtained from questionnaires and clinical records. In venous blood samples we measured cytokines and adipose-tissue specific secretion proteins. Serum magnesium concentrations were measured and correlated with clinical data and laboratory measurements using univariate and multivariate regression models. Hierarchical multiple regression of serum magnesium with insulin resistance was adjusted for diabetes and potential magnesium confounders. The prevalence of hypomagnesemia (serum magnesium levels < 0.7 mmol/L) was 2.9% in a cohort consisting of 241 individuals with type 1 diabetes. The magnesium concentration in the cohort was not associated with HbA(1c) (r = − 0.12, P-value = 0.068) nor with any inflammatory marker or adipokine. However, insulin dose (IU/kg), a surrogate measure of resistance in type 1 diabetes, moderated the association of serum magnesium (mmol/L) with HbA(1c) (mmol/mol) with a B coefficient of − 71.91 (95% CI: − 119.11; -24.71), P-value = 0.003) and Log(10) high-sensitivity C-reactive protein (Log(10) mg/L) − 2.09 (95% CI: − 3.70; − 0.48), P-value = 0.011). The association of low serum magnesium levels with glycaemic control (HbA(1c)) and high-sensitivity C-reactive protein in individuals with type 1 diabetes is limited to subjects using a high insulin dose and suggests that insulin resistance, a type 2 diabetes feature, is a prerequisite for hypomagnesemia. Nature Publishing Group UK 2022-04-19 /pmc/articles/PMC9018833/ /pubmed/35440685 http://dx.doi.org/10.1038/s41598-022-10436-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Oost, Lynette J. van Heck, Julia I. P. Tack, Cees J. de Baaij, Jeroen H. F. The association between hypomagnesemia and poor glycaemic control in type 1 diabetes is limited to insulin resistant individuals |
title | The association between hypomagnesemia and poor glycaemic control in type 1 diabetes is limited to insulin resistant individuals |
title_full | The association between hypomagnesemia and poor glycaemic control in type 1 diabetes is limited to insulin resistant individuals |
title_fullStr | The association between hypomagnesemia and poor glycaemic control in type 1 diabetes is limited to insulin resistant individuals |
title_full_unstemmed | The association between hypomagnesemia and poor glycaemic control in type 1 diabetes is limited to insulin resistant individuals |
title_short | The association between hypomagnesemia and poor glycaemic control in type 1 diabetes is limited to insulin resistant individuals |
title_sort | association between hypomagnesemia and poor glycaemic control in type 1 diabetes is limited to insulin resistant individuals |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018833/ https://www.ncbi.nlm.nih.gov/pubmed/35440685 http://dx.doi.org/10.1038/s41598-022-10436-0 |
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