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MFG-E8 alleviates intervertebral disc degeneration by suppressing pyroptosis and extracellular matrix degradation in nucleus pulposus cells via Nrf2/TXNIP/NLRP3 axis

Intervertebral disc degeneration (IVDD) is a chronic age-related degenerative disease accompanied by complex pathophysiological mechanisms. Increasing evidence indicates that NLRP3 inflammasome mediated pyroptosis of nucleus pulposus (NP) cells displays an important role in the pathological progress...

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Detalles Bibliográficos
Autores principales:	Ma, Haiwei, Xie, Chenglong, Chen, Zhengtai, He, Gaolu, Dai, Zihan, Cai, Hanchen, Zhang, Haojie, Lu, Hongwei, Wu, Hongqiang, Hu, Xinli, Zhou, Kailiang, Zheng, Gang, Xu, Huazi, Xu, Cong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018842/ https://www.ncbi.nlm.nih.gov/pubmed/35440086 http://dx.doi.org/10.1038/s41420-022-01002-8

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