A leukemia-protective germline variant mediates chromatin module formation via transcription factor nucleation

Non-coding variants coordinate transcription factor (TF) binding and chromatin mark enrichment changes over regions spanning >100 kb. These molecularly coordinated regions are named “variable chromatin modules” (VCMs), providing a conceptual framework of how regulatory variation might shape compl...

Descripción completa

Detalles Bibliográficos
Autores principales: Llimos, Gerard, Gardeux, Vincent, Koch, Ute, Kribelbauer, Judith F., Hafner, Antonina, Alpern, Daniel, Pezoldt, Joern, Litovchenko, Maria, Russeil, Julie, Dainese, Riccardo, Moia, Riccardo, Mahmoud, Abdurraouf Mokhtar, Rossi, Davide, Gaidano, Gianluca, Plass, Christoph, Lutsik, Pavlo, Gerhauser, Clarissa, Waszak, Sebastian M., Boettiger, Alistair, Radtke, Freddy, Deplancke, Bart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018852/
https://www.ncbi.nlm.nih.gov/pubmed/35440565
http://dx.doi.org/10.1038/s41467-022-29625-6

Ejemplares similares

Ejemplares similares