Naloxone’s dose-dependent displacement of [(11)C]carfentanil and duration of receptor occupancy in the rat brain

The continuous rise in opioid overdoses in the United States is predominantly driven by very potent synthetic opioids, mostly fentanyl and its derivatives (fentanyls). Although naloxone (NLX) has been shown to effectively reverse overdoses by conventional opioids, there may be a need for higher or r...

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Detalles Bibliográficos
Autores principales: Kang, Yeona, O’Conor, Kelly A., Kelleher, Andrew C., Ramsey, Joseph, Bakhoda, Abolghasem, Eisenberg, Seth M., Zhao, Wenjing, Stodden, Tyler, Pearson, Torben D., Guo, Min, Brown, Nina, Liow, Jeih-San, Fowler, Joanna S., Kim, Sung Won, Volkow, Nora D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018944/
https://www.ncbi.nlm.nih.gov/pubmed/35440607
http://dx.doi.org/10.1038/s41598-022-09601-2

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