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The Importance of Being Presented: Target Validation by Immunopeptidomics for Epitope-Specific Immunotherapies
Presentation of tumor-specific or tumor-associated peptides by HLA class I molecules to CD8(+) T cells is the foundation of epitope-centric cancer immunotherapies. While often in silico HLA binding predictions or in vitro immunogenicity assays are utilized to select candidates, mass spectrometry-bas...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018990/ https://www.ncbi.nlm.nih.gov/pubmed/35464395 http://dx.doi.org/10.3389/fimmu.2022.883989 |