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The Importance of Being Presented: Target Validation by Immunopeptidomics for Epitope-Specific Immunotherapies

Presentation of tumor-specific or tumor-associated peptides by HLA class I molecules to CD8(+) T cells is the foundation of epitope-centric cancer immunotherapies. While often in silico HLA binding predictions or in vitro immunogenicity assays are utilized to select candidates, mass spectrometry-bas...

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Detalles Bibliográficos
Autores principales: Becker, Jonas P., Riemer, Angelika B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018990/
https://www.ncbi.nlm.nih.gov/pubmed/35464395
http://dx.doi.org/10.3389/fimmu.2022.883989

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