Cargando…

Generation of human islet cell type-specific identity genesets

Generation of surrogate cells with stable functional identities is crucial for developing cell-based therapies. Efforts to produce insulin-secreting replacement cells to treat diabetes require reliable tools to assess islet cellular identity. Here, we conduct a thorough single-cell transcriptomics m...

Descripción completa

Detalles Bibliográficos
Autores principales:	van Gurp, Léon, Fodoulian, Leon, Oropeza, Daniel, Furuyama, Kenichiro, Bru-Tari, Eva, Vu, Anh Nguyet, Kaddis, John S., Rodríguez, Iván, Thorel, Fabrizio, Herrera, Pedro L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019032/ https://www.ncbi.nlm.nih.gov/pubmed/35440614 http://dx.doi.org/10.1038/s41467-022-29588-8

Ejemplares similares

Author Correction: Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production
por: Perez-Frances, Marta, et al.
Publicado: (2021)

Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production
por: Perez-Frances, Marta, et al.
Publicado: (2021)

Pancreatic Islet-Autonomous Insulin and Smoothened-Mediated Signaling Modulate Identity Changes of Glucagon(+) α-Cells
por: Cigliola, Valentina, et al.
Publicado: (2018)

Cell Heterogeneity and Paracrine Interactions in Human Islet Function: A Perspective Focused in β-Cell Regeneration Strategies
por: Bru-Tari, Eva, et al.
Publicado: (2021)

Diabetes Relief in Mice by Glucose-Sensing Insulin-Secreting Human α-Cells
por: Furuyama, Kenichiro, et al.
Publicado: (2019)

PyGNA: a unified framework for geneset network analysis
por: Fanfani, Viola, et al.
Publicado: (2020)

Overrepresentation of transcription factor families in the genesets underlying breast cancer subtypes
por: Joshi, Himanshu, et al.
Publicado: (2012)

A comparison of the genes and genesets identified by GWAS and EWAS of fifteen complex traits
por: Battram, Thomas, et al.
Publicado: (2022)

Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity
por: Horgue, Luis Flores, et al.
Publicado: (2022)

Low risk for diabetic complications in type 1 diabetes patients carrying a protective insulin gene variant
por: van Tienhoven, René, et al.
Publicado: (2023)

Publisher Correction: Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity
por: Horgue, Luis Flores, et al.
Publicado: (2023)

Application of text mining to develop AOP-based mucus hypersecretion genesets and confirmation with in vitro and clinical samples
por: Minet, Emmanuel, et al.
Publicado: (2021)

Adult pancreatic islet endocrine cells emerge as fetal hormone-expressing cells
por: Perez-Frances, Marta, et al.
Publicado: (2022)

Comparison of GENCODE and RefSeq gene annotation and the impact of reference geneset on variant effect prediction
por: Frankish, Adam, et al.
Publicado: (2015)

In silico analysis of differentially expressed genesets in metastatic breast cancer identifies potential prognostic biomarkers
por: Kim, Jongchan
Publicado: (2021)

MyGeneset.info: an interactive and programmatic platform for community-curated and user-created collections of genes
por: Avila, Ricardo, et al.
Publicado: (2023)

GeneSet2miRNA: finding the signature of cooperative miRNA activities in the gene lists
por: Antonov, Alexey V., et al.
Publicado: (2009)

Diabetes Recovery By Age-Dependent Conversion of Pancreatic δ-Cells Into Insulin Producers
por: Chera, Simona, et al.
Publicado: (2014)

Comprehensive omics analyses profile genesets related with tumor heterogeneity of multifocal glioblastomas and reveal LIF/CCL2 as biomarkers for mesenchymal subtype
por: Lv, Sheng-Qing, et al.
Publicado: (2022)

Improving the Prediction of Type 1 Diabetes Across Ancestries
por: Kaddis, John S., et al.
Publicado: (2022)

In Vivo Conditional Pax4 Overexpression in Mature Islet β-Cells Prevents Stress-Induced Hyperglycemia in Mice
por: He, Kai Hui Hu, et al.
Publicado: (2011)

Nkx6.1 Controls a Gene Regulatory Network Required for Establishing and Maintaining Pancreatic Beta Cell Identity
por: Schaffer, Ashleigh E., et al.
Publicado: (2013)

Dynamic perceptual feature selectivity in primary somatosensory cortex upon reversal learning
por: Chéreau, Ronan, et al.
Publicado: (2020)

From type 1 diabetes biology to therapy: The Human Islet Research Network
por: Kaddis, John S., et al.
Publicado: (2021)

Clustering of vomeronasal receptor genes is required for transcriptional stability but not for choice
por: Dietschi, Quentin, et al.
Publicado: (2022)

Chronic marijuana usage by human pancreas donors is associated with impaired islet function
por: Qi, Meirigeng, et al.
Publicado: (2021)

Conversion of Adult Pancreatic α-cells to β-cells After Extreme β-cell Loss
por: Thorel, Fabrizio, et al.
Publicado: (2010)

Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes
por: Richardson, Sarah J., et al.
Publicado: (2016)

Targeting GLP-1 receptors for repeated magnetic resonance imaging differentiates graded losses of pancreatic beta cells in mice
por: Vinet, Laurent, et al.
Publicado: (2014)

Species-specific roles for the MAFA and MAFB transcription factors in regulating islet β cell identity
por: Cha, Jeeyeon, et al.
Publicado: (2023)

Normal Glucagon Signaling and β-Cell Function After Near-Total α-Cell Ablation in Adult Mice
por: Thorel, Fabrizio, et al.
Publicado: (2011)

Blockade of glucagon signaling prevents or reverses diabetes onset only if residual β-cells persist
por: Damond, Nicolas, et al.
Publicado: (2016)

SARS-CoV-2 Receptors and Entry Genes Are Expressed in the Human Olfactory Neuroepithelium and Brain
por: Fodoulian, Leon, et al.
Publicado: (2020)

Tolerogenic dendritic cells pulsed with islet antigen induce long-term reduction in T-cell autoreactivity in type 1 diabetes patients
por: Nikolic, Tatjana, et al.
Publicado: (2022)

Evidence for Loss in Identity, De-Differentiation, and Trans-Differentiation of Islet β-Cells in Type 2 Diabetes
por: Hunter, Chad S., et al.
Publicado: (2017)

The SSBP3 co-regulator is required for glucose homeostasis, pancreatic islet architecture, and beta-cell identity
por: Toren, Eliana, et al.
Publicado: (2023)

Loss of Prohibitin Induces Mitochondrial Damages Altering β-Cell Function and Survival and Is Responsible for Gradual Diabetes Development
por: Supale, Sachin, et al.
Publicado: (2013)

Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet α-Cells Into β-Cells In Vivo
por: Matsuoka, Taka-aki, et al.
Publicado: (2017)

Connective Tissue Growth Factor Modulates Adult β-Cell Maturity and Proliferation to Promote β-Cell Regeneration in Mice
por: Riley, Kimberly G., et al.
Publicado: (2015)

Pancreatic alpha-cell mass in the early-onset and advanced stage of a mouse model of experimental autoimmune diabetes
por: Bru-Tari, Eva, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_477vc8kgthg4gosamdmhri5q74