Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms

Modulation of protein abundance using tag-Targeted Protein Degrader (tTPD) systems targeting FKBP12(F36V) (dTAGs) or HaloTag7 (HaloPROTACs) are powerful approaches for preclinical target validation. Interchanging tags and tag-targeting degraders is important to achieve efficient substrate degradatio...

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Detalles Bibliográficos
Autores principales: Grohmann, Christoph, Magtoto, Charlene M., Walker, Joel R., Chua, Ngee Kiat, Gabrielyan, Anna, Hall, Mary, Cobbold, Simon A., Mieruszynski, Stephen, Brzozowski, Martin, Simpson, Daniel S., Dong, Hao, Dorizzi, Bridget, Jacobsen, Annette V., Morrish, Emma, Silke, Natasha, Murphy, James M., Heath, Joan K., Testa, Andrea, Maniaci, Chiara, Ciulli, Alessio, Lessene, Guillaume, Silke, John, Feltham, Rebecca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019100/
https://www.ncbi.nlm.nih.gov/pubmed/35440107
http://dx.doi.org/10.1038/s41467-022-29670-1

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