Alkylating anticancer agents and their relations to microRNAs

Alkylating agents represent an important class of anticancer drugs. The occurrence and emergence of tumor resistance to the treatment with alkylating agents denotes a severe problem in the clinics. A detailed understanding of the mechanisms of activity of alkylating drugs is essential in order to ov...

Descripción completa

Detalles Bibliográficos
Autor principal: Biersack, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: OAE Publishing Inc. 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019174/
https://www.ncbi.nlm.nih.gov/pubmed/35582140
http://dx.doi.org/10.20517/cdr.2019.09
_version_ 1784689196976308224
author Biersack, Bernhard
author_facet Biersack, Bernhard
author_sort Biersack, Bernhard
collection PubMed
description Alkylating agents represent an important class of anticancer drugs. The occurrence and emergence of tumor resistance to the treatment with alkylating agents denotes a severe problem in the clinics. A detailed understanding of the mechanisms of activity of alkylating drugs is essential in order to overcome drug resistance. In particular, the role of non-coding microRNAs concerning alkylating drug activity and resistance in various cancers is highlighted in this review. Both synthetic and natural alkylating agents, which are approved for cancer therapy, are discussed concerning their interplay with microRNAs.
format Online
Article
Text
id pubmed-9019174
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher OAE Publishing Inc.
record_format MEDLINE/PubMed
spelling pubmed-90191742022-05-16 Alkylating anticancer agents and their relations to microRNAs Biersack, Bernhard Cancer Drug Resist Review Alkylating agents represent an important class of anticancer drugs. The occurrence and emergence of tumor resistance to the treatment with alkylating agents denotes a severe problem in the clinics. A detailed understanding of the mechanisms of activity of alkylating drugs is essential in order to overcome drug resistance. In particular, the role of non-coding microRNAs concerning alkylating drug activity and resistance in various cancers is highlighted in this review. Both synthetic and natural alkylating agents, which are approved for cancer therapy, are discussed concerning their interplay with microRNAs. OAE Publishing Inc. 2019-03-19 /pmc/articles/PMC9019174/ /pubmed/35582140 http://dx.doi.org/10.20517/cdr.2019.09 Text en © The Author(s) 2019. https://creativecommons.org/licenses/by/4.0/© The Author(s) 2019. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Biersack, Bernhard
Alkylating anticancer agents and their relations to microRNAs
title Alkylating anticancer agents and their relations to microRNAs
title_full Alkylating anticancer agents and their relations to microRNAs
title_fullStr Alkylating anticancer agents and their relations to microRNAs
title_full_unstemmed Alkylating anticancer agents and their relations to microRNAs
title_short Alkylating anticancer agents and their relations to microRNAs
title_sort alkylating anticancer agents and their relations to micrornas
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019174/
https://www.ncbi.nlm.nih.gov/pubmed/35582140
http://dx.doi.org/10.20517/cdr.2019.09
work_keys_str_mv AT biersackbernhard alkylatinganticanceragentsandtheirrelationstomicrornas

Ejemplares similares