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Resistance to anti-tubulin agents: From vinca alkaloids to epothilones
This review describes the mechanism of action - inhibition of microtubules - and the most important mechanisms of resistance for vinca alkaloids, taxanes and epothilones. Resistance is a major problem in vinca and taxane chemotherapy and arises in most cases from overexpression of efflux pumps that...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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OAE Publishing Inc.
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019178/ https://www.ncbi.nlm.nih.gov/pubmed/35582143 http://dx.doi.org/10.20517/cdr.2019.06 |