Modeling the CRL4A ligase complex to predict target protein ubiquitination induced by cereblon-recruiting PROTACs

PROteolysis TArgeting Chimeras (PROTACs) are hetero-bifunctional small molecules that can simultaneously recruit target proteins and E3 ligases to form a ternary complex, promoting target protein ubiquitination and degradation via the Ubiquitin-Proteasome System (UPS). PROTACs have gained increasing...

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Detalles Bibliográficos
Autores principales: Bai, Nan, Riching, Kristin M., Makaju, Aman, Wu, Hao, Acker, Timothy M., Ou, Shu-Ching, Zhang, Yaru, Shen, Xiaomeng, Bulloch, Daryl N., Rui, Huan, Gibson, Bradford W., Daniels, Danette L., Urh, Marjeta, Rock, Brooke M., Humphreys, Sara C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019245/
https://www.ncbi.nlm.nih.gov/pubmed/35101445
http://dx.doi.org/10.1016/j.jbc.2022.101653

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