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Calmodulin activates the Hippo signaling pathway by promoting LATS1 kinase–mediated inhibitory phosphorylation of the transcriptional coactivator YAP

The Hippo signaling pathway regulates tissue growth and cell fate, and its dysregulation can induce tumorigenesis. When Hippo is activated by cell–cell contact, extracellular signals, or cell polarity among others, the large tumor suppressor 1 (LATS1) kinase catalyzes inhibitory phosphorylation of t...

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Detalles Bibliográficos
Autores principales:	Thines, Louise, Gorisse, Laëtitia, Li, Zhigang, Sayedyahossein, Samar, Sacks, David B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019248/ https://www.ncbi.nlm.nih.gov/pubmed/35307353 http://dx.doi.org/10.1016/j.jbc.2022.101839

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