Paip2A inhibits translation by competitively binding to the RNA recognition motifs of PABPC1 and promoting its dissociation from the poly(A) tail

Eukaryotic mRNAs possess a poly(A) tail at their 3′-end, to which poly(A)-binding protein C1 (PABPC1) binds and recruits other proteins that regulate translation. Enhanced poly(A)-dependent translation, which is also PABPC1 dependent, promotes cellular and viral proliferation. PABP-interacting prote...

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Detalles Bibliográficos
Autores principales: Sagae, Takeru, Yokogawa, Mariko, Sawazaki, Ryoichi, Ishii, Yuichiro, Hosoda, Nao, Hoshino, Shin-ichi, Imai, Shunsuke, Shimada, Ichio, Osawa, Masanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019252/
https://www.ncbi.nlm.nih.gov/pubmed/35307347
http://dx.doi.org/10.1016/j.jbc.2022.101844

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