Trophic factor BDNF inhibits GABAergic signaling by facilitating dendritic enrichment of SUMO E3 ligase PIAS3 and altering gephyrin scaffold

Posttranslational addition of a small ubiquitin-like modifier (SUMO) moiety (SUMOylation) has been implicated in pathologies such as brain ischemia, diabetic peripheral neuropathy, and neurodegeneration. However, nuclear enrichment of SUMO pathway proteins has made it difficult to ascertain how ion...

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Detalles Bibliográficos
Autores principales: Thirouin, Zahra S., Figueiredo, Marta, Hleihil, Mohammad, Gill, Raminder, Bosshard, Giovanna, McKinney, R Anne, Tyagarajan, Shiva K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019257/
https://www.ncbi.nlm.nih.gov/pubmed/35307349
http://dx.doi.org/10.1016/j.jbc.2022.101840

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