The emerging roles of E3 ubiquitin ligases in ovarian cancer chemoresistance

Epithelial cancer of the ovary exhibits the highest mortality rate of all gynecological malignancies in women today, since the disease is often diagnosed in advanced stages. While the treatment of cancer with specific chemical agents or drugs is the favored treatment regimen, chemotherapy resistance...

Descripción completa

Detalles Bibliográficos
Autores principales: Meng, Yang, Qiu, Lei, Zhang, Su, Han, Junhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: OAE Publishing Inc. 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019267/
https://www.ncbi.nlm.nih.gov/pubmed/35582023
http://dx.doi.org/10.20517/cdr.2020.115
_version_ 1784689222129549312
author Meng, Yang
Qiu, Lei
Zhang, Su
Han, Junhong
author_facet Meng, Yang
Qiu, Lei
Zhang, Su
Han, Junhong
author_sort Meng, Yang
collection PubMed
description Epithelial cancer of the ovary exhibits the highest mortality rate of all gynecological malignancies in women today, since the disease is often diagnosed in advanced stages. While the treatment of cancer with specific chemical agents or drugs is the favored treatment regimen, chemotherapy resistance greatly impedes successful ovarian cancer chemotherapy. Thus, chemoresistance becomes one of the most critical clinical issues confronted when treating patients with ovarian cancer. Convincing evidence hints that dysregulation of E3 ubiquitin ligases is a key factor in the development and maintenance of ovarian cancer chemoresistance. This review outlines recent advancement in our understanding of the emerging roles of E3 ubiquitin ligases in ovarian cancer chemoresistance. We also highlight currently available inhibitors targeting E3 ligase activities and discuss their potential for clinical applications in treating chemoresistant ovarian cancer patients.
format Online
Article
Text
id pubmed-9019267
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher OAE Publishing Inc.
record_format MEDLINE/PubMed
spelling pubmed-90192672022-05-16 The emerging roles of E3 ubiquitin ligases in ovarian cancer chemoresistance Meng, Yang Qiu, Lei Zhang, Su Han, Junhong Cancer Drug Resist Review Epithelial cancer of the ovary exhibits the highest mortality rate of all gynecological malignancies in women today, since the disease is often diagnosed in advanced stages. While the treatment of cancer with specific chemical agents or drugs is the favored treatment regimen, chemotherapy resistance greatly impedes successful ovarian cancer chemotherapy. Thus, chemoresistance becomes one of the most critical clinical issues confronted when treating patients with ovarian cancer. Convincing evidence hints that dysregulation of E3 ubiquitin ligases is a key factor in the development and maintenance of ovarian cancer chemoresistance. This review outlines recent advancement in our understanding of the emerging roles of E3 ubiquitin ligases in ovarian cancer chemoresistance. We also highlight currently available inhibitors targeting E3 ligase activities and discuss their potential for clinical applications in treating chemoresistant ovarian cancer patients. OAE Publishing Inc. 2021-06-19 /pmc/articles/PMC9019267/ /pubmed/35582023 http://dx.doi.org/10.20517/cdr.2020.115 Text en © The Author(s) 2021. https://creativecommons.org/licenses/by/4.0/© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Meng, Yang
Qiu, Lei
Zhang, Su
Han, Junhong
The emerging roles of E3 ubiquitin ligases in ovarian cancer chemoresistance
title The emerging roles of E3 ubiquitin ligases in ovarian cancer chemoresistance
title_full The emerging roles of E3 ubiquitin ligases in ovarian cancer chemoresistance
title_fullStr The emerging roles of E3 ubiquitin ligases in ovarian cancer chemoresistance
title_full_unstemmed The emerging roles of E3 ubiquitin ligases in ovarian cancer chemoresistance
title_short The emerging roles of E3 ubiquitin ligases in ovarian cancer chemoresistance
title_sort emerging roles of e3 ubiquitin ligases in ovarian cancer chemoresistance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019267/
https://www.ncbi.nlm.nih.gov/pubmed/35582023
http://dx.doi.org/10.20517/cdr.2020.115
work_keys_str_mv AT mengyang theemergingrolesofe3ubiquitinligasesinovariancancerchemoresistance
AT qiulei theemergingrolesofe3ubiquitinligasesinovariancancerchemoresistance
AT zhangsu theemergingrolesofe3ubiquitinligasesinovariancancerchemoresistance
AT hanjunhong theemergingrolesofe3ubiquitinligasesinovariancancerchemoresistance
AT mengyang emergingrolesofe3ubiquitinligasesinovariancancerchemoresistance
AT qiulei emergingrolesofe3ubiquitinligasesinovariancancerchemoresistance
AT zhangsu emergingrolesofe3ubiquitinligasesinovariancancerchemoresistance
AT hanjunhong emergingrolesofe3ubiquitinligasesinovariancancerchemoresistance

Ejemplares similares