Cargando…
The Impact of Traditional Chinese Medicine QingreHuoxue Treatment and the Combination of Methotrexate and Hydroxychloroquine on the Radiological Progression of Active Rheumatoid Arthritis: A 52-Week Follow-Up of a Randomized Controlled Clinical Study
Traditional Chinese medicine (TCM) has been used successfully to treat rheumatoid arthritis (RA). QingreHuoxue treatment (QingreHuoxue decoction [QRHXD]/QingreHuoxue external preparation [QRHXEP]) is a Chinese medicine treatment for RA. To date, very few studies have compared the long-term effects o...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019417/ https://www.ncbi.nlm.nih.gov/pubmed/35463097 http://dx.doi.org/10.1155/2022/5808400 |
_version_ | 1784689269526233088 |
---|---|
author | Zhang, Rouman Tang, Xiao-Po Wang, Jian Liu, Wei-Xiang Liu, Jian Wang, Yue Liu, Wei Fang, Yong-Fei He, Dong-Yi Liu, Ying Gao, Ming-Li Wu, Qing-Jun Li, Zhen-Bin Chen, Shi Huang, Qing-Chun Xie, Yan-Ming Zhang, Jun-Li Zhou, Cai-Yun Ma, Li Wang, Xin-Chang Jiang, Quan Gong, Xun |
author_facet | Zhang, Rouman Tang, Xiao-Po Wang, Jian Liu, Wei-Xiang Liu, Jian Wang, Yue Liu, Wei Fang, Yong-Fei He, Dong-Yi Liu, Ying Gao, Ming-Li Wu, Qing-Jun Li, Zhen-Bin Chen, Shi Huang, Qing-Chun Xie, Yan-Ming Zhang, Jun-Li Zhou, Cai-Yun Ma, Li Wang, Xin-Chang Jiang, Quan Gong, Xun |
author_sort | Zhang, Rouman |
collection | PubMed |
description | Traditional Chinese medicine (TCM) has been used successfully to treat rheumatoid arthritis (RA). QingreHuoxue treatment (QingreHuoxue decoction [QRHXD]/QingreHuoxue external preparation [QRHXEP]) is a Chinese medicine treatment for RA. To date, very few studies have compared the long-term effects of QRHXD with those of conventional disease-modifying antirheumatic drugs on RA disease activity and radiological progression. QRHXD delayed the radiological progression and showed long-term clinical efficacy of RA. In clinical experiments, the clinical evidence of delaying the radiological progression of RA patients was obtained. A portion of the patients who participated in the “Traditional Chinese Medicine QingreHuoxue Treatment vs. the Combination of Methotrexate and Hydroxychloroquine for Active Rheumatoid Arthritis” study were followed up for 52 weeks, and intention-to-treat (ITT) and compliance protocol (PP) analyses were used to collect and compare the clinical indicators and imaging data between baseline and week 52. Two radiologists who were blind to treatment scored the images independently. Of the 468 subjects, 141 completed the 52-week follow-up. There were no significant differences among the three groups: the traditional Chinese medicine comprehensive treatment group, the Western medicine treatment group, and the integrated traditional Chinese and Western medicine treatment group. There were no differences in the total Sharp score, joint space stenosis score, and joint erosion score at baseline or 52 weeks. In the comparison of the estimated annual radiographic progression (EARP) and the actual annual Sharp total score changes among the three groups, the actual changes were much lower than the EARP at baseline. The radiological progress in all three groups was well controlled. Results of the ITT and PP data sets showed that the disease activity score 28 level of the three groups at 52 weeks was significantly lower than that at baseline. During the 52-week treatment period, the clearance of heat and promotion of blood circulation controlled disease activity and delayed the radiological progress of active RA. |
format | Online Article Text |
id | pubmed-9019417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-90194172022-04-21 The Impact of Traditional Chinese Medicine QingreHuoxue Treatment and the Combination of Methotrexate and Hydroxychloroquine on the Radiological Progression of Active Rheumatoid Arthritis: A 52-Week Follow-Up of a Randomized Controlled Clinical Study Zhang, Rouman Tang, Xiao-Po Wang, Jian Liu, Wei-Xiang Liu, Jian Wang, Yue Liu, Wei Fang, Yong-Fei He, Dong-Yi Liu, Ying Gao, Ming-Li Wu, Qing-Jun Li, Zhen-Bin Chen, Shi Huang, Qing-Chun Xie, Yan-Ming Zhang, Jun-Li Zhou, Cai-Yun Ma, Li Wang, Xin-Chang Jiang, Quan Gong, Xun Evid Based Complement Alternat Med Research Article Traditional Chinese medicine (TCM) has been used successfully to treat rheumatoid arthritis (RA). QingreHuoxue treatment (QingreHuoxue decoction [QRHXD]/QingreHuoxue external preparation [QRHXEP]) is a Chinese medicine treatment for RA. To date, very few studies have compared the long-term effects of QRHXD with those of conventional disease-modifying antirheumatic drugs on RA disease activity and radiological progression. QRHXD delayed the radiological progression and showed long-term clinical efficacy of RA. In clinical experiments, the clinical evidence of delaying the radiological progression of RA patients was obtained. A portion of the patients who participated in the “Traditional Chinese Medicine QingreHuoxue Treatment vs. the Combination of Methotrexate and Hydroxychloroquine for Active Rheumatoid Arthritis” study were followed up for 52 weeks, and intention-to-treat (ITT) and compliance protocol (PP) analyses were used to collect and compare the clinical indicators and imaging data between baseline and week 52. Two radiologists who were blind to treatment scored the images independently. Of the 468 subjects, 141 completed the 52-week follow-up. There were no significant differences among the three groups: the traditional Chinese medicine comprehensive treatment group, the Western medicine treatment group, and the integrated traditional Chinese and Western medicine treatment group. There were no differences in the total Sharp score, joint space stenosis score, and joint erosion score at baseline or 52 weeks. In the comparison of the estimated annual radiographic progression (EARP) and the actual annual Sharp total score changes among the three groups, the actual changes were much lower than the EARP at baseline. The radiological progress in all three groups was well controlled. Results of the ITT and PP data sets showed that the disease activity score 28 level of the three groups at 52 weeks was significantly lower than that at baseline. During the 52-week treatment period, the clearance of heat and promotion of blood circulation controlled disease activity and delayed the radiological progress of active RA. Hindawi 2022-04-12 /pmc/articles/PMC9019417/ /pubmed/35463097 http://dx.doi.org/10.1155/2022/5808400 Text en Copyright © 2022 Rouman Zhang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhang, Rouman Tang, Xiao-Po Wang, Jian Liu, Wei-Xiang Liu, Jian Wang, Yue Liu, Wei Fang, Yong-Fei He, Dong-Yi Liu, Ying Gao, Ming-Li Wu, Qing-Jun Li, Zhen-Bin Chen, Shi Huang, Qing-Chun Xie, Yan-Ming Zhang, Jun-Li Zhou, Cai-Yun Ma, Li Wang, Xin-Chang Jiang, Quan Gong, Xun The Impact of Traditional Chinese Medicine QingreHuoxue Treatment and the Combination of Methotrexate and Hydroxychloroquine on the Radiological Progression of Active Rheumatoid Arthritis: A 52-Week Follow-Up of a Randomized Controlled Clinical Study |
title | The Impact of Traditional Chinese Medicine QingreHuoxue Treatment and the Combination of Methotrexate and Hydroxychloroquine on the Radiological Progression of Active Rheumatoid Arthritis: A 52-Week Follow-Up of a Randomized Controlled Clinical Study |
title_full | The Impact of Traditional Chinese Medicine QingreHuoxue Treatment and the Combination of Methotrexate and Hydroxychloroquine on the Radiological Progression of Active Rheumatoid Arthritis: A 52-Week Follow-Up of a Randomized Controlled Clinical Study |
title_fullStr | The Impact of Traditional Chinese Medicine QingreHuoxue Treatment and the Combination of Methotrexate and Hydroxychloroquine on the Radiological Progression of Active Rheumatoid Arthritis: A 52-Week Follow-Up of a Randomized Controlled Clinical Study |
title_full_unstemmed | The Impact of Traditional Chinese Medicine QingreHuoxue Treatment and the Combination of Methotrexate and Hydroxychloroquine on the Radiological Progression of Active Rheumatoid Arthritis: A 52-Week Follow-Up of a Randomized Controlled Clinical Study |
title_short | The Impact of Traditional Chinese Medicine QingreHuoxue Treatment and the Combination of Methotrexate and Hydroxychloroquine on the Radiological Progression of Active Rheumatoid Arthritis: A 52-Week Follow-Up of a Randomized Controlled Clinical Study |
title_sort | impact of traditional chinese medicine qingrehuoxue treatment and the combination of methotrexate and hydroxychloroquine on the radiological progression of active rheumatoid arthritis: a 52-week follow-up of a randomized controlled clinical study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019417/ https://www.ncbi.nlm.nih.gov/pubmed/35463097 http://dx.doi.org/10.1155/2022/5808400 |
work_keys_str_mv | AT zhangrouman theimpactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT tangxiaopo theimpactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT wangjian theimpactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT liuweixiang theimpactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT liujian theimpactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT wangyue theimpactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT liuwei theimpactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT fangyongfei theimpactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT hedongyi theimpactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT liuying theimpactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT gaomingli theimpactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT wuqingjun theimpactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT lizhenbin theimpactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT chenshi theimpactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT huangqingchun theimpactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT xieyanming theimpactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT zhangjunli theimpactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT zhoucaiyun theimpactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT mali theimpactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT wangxinchang theimpactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT jiangquan theimpactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT gongxun theimpactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT zhangrouman impactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT tangxiaopo impactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT wangjian impactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT liuweixiang impactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT liujian impactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT wangyue impactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT liuwei impactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT fangyongfei impactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT hedongyi impactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT liuying impactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT gaomingli impactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT wuqingjun impactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT lizhenbin impactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT chenshi impactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT huangqingchun impactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT xieyanming impactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT zhangjunli impactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT zhoucaiyun impactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT mali impactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT wangxinchang impactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT jiangquan impactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy AT gongxun impactoftraditionalchinesemedicineqingrehuoxuetreatmentandthecombinationofmethotrexateandhydroxychloroquineontheradiologicalprogressionofactiverheumatoidarthritisa52weekfollowupofarandomizedcontrolledclinicalstudy |