RANKL Impairs the TLR4 Pathway by Increasing TRAF6 and RANK Interaction in Macrophages

High serum levels of osteoprotegerin (OPG) are found in patients with obesity, type 2 diabetes, sepsis, or septic shock and are associated with a high mortality rate in stroke. The primary known function of OPG is to bind to the receptor activator of NF-κB ligand (RANKL), and by doing so, it inhibit...

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Detalles Bibliográficos
Autores principales: Mota, Ryerson Fonseca, Cavalcanti de Araújo, Paulo Henrique, Cezine, Maria Eduarda Ramos, Matsuo, Flávia Sayuri, Metzner, Rodrigo Jair Morandi, Oliveira de Biagi Junior, Carlos Alberto, Peronni, Kamila Chagas, Hayashi, Hiroki, Shimamura, Munehisa, Nakagami, Hironori, Osako, Mariana Kiomy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019442/
https://www.ncbi.nlm.nih.gov/pubmed/35463988
http://dx.doi.org/10.1155/2022/7740079

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