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SHP2 Inhibitors Show Anti-Myeloma Activity and Synergize With Bortezomib in the Treatment of Multiple Myeloma

Multiple myeloma (MM) is a plasma cell malignancy that remains incurable. The protein tyrosine phosphatase SHP2 is a central node regulating RAS/mitogen-activated protein kinase (MAPK)/extracellular signal regulated kinase (ERK) signaling pathway which plays a crucial role in the pathogenesis and pr...

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Detalles Bibliográficos
Autores principales:	Zhou, Pan, Xiao, Mengyu, Li, Weiya, Sun, Xiaobai, Bai, Yanliang, Meng, Feiying, Zhu, Zunmin, Yuan, Weiping, Sun, Kai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019471/ https://www.ncbi.nlm.nih.gov/pubmed/35462913 http://dx.doi.org/10.3389/fphar.2022.841308

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