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Maternal Exposure to Polychlorinated Biphenyls and Asthma, Allergic Rhinitis and Atopic Dermatitis in the Offspring: The Environmental Health Fund Birth Cohort

Background: Polychlorinated biphenyls (PCBs) are persistent organic pollutants banned for use worldwide. Due to their biodegradation resistance, they accumulate along the food chain and in the environment. Maternal exposure to PCBs may affect the fetus and the infant. PCBs are immunotoxic and may da...

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Autores principales: Berlin, Maya, Flor-Hirsch, Hadar, Kohn, Elkana, Brik, Anna, Keidar, Rimona, Livne, Ayelet, Marom, Ronella, Ovental, Amit, Mandel, Dror, Lubetzky, Ronit, Factor-Litvak, Pam, Tovbin, Josef, Betser, Moshe, Moskovich, Miki, Hazan, Ariela, Britzi, Malka, Gueta, Itai, Berkovitch, Matitiahu, Matok, Ilan, Hamiel, Uri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019472/
https://www.ncbi.nlm.nih.gov/pubmed/35462915
http://dx.doi.org/10.3389/fphar.2022.802974
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author Berlin, Maya
Flor-Hirsch, Hadar
Kohn, Elkana
Brik, Anna
Keidar, Rimona
Livne, Ayelet
Marom, Ronella
Ovental, Amit
Mandel, Dror
Lubetzky, Ronit
Factor-Litvak, Pam
Tovbin, Josef
Betser, Moshe
Moskovich, Miki
Hazan, Ariela
Britzi, Malka
Gueta, Itai
Berkovitch, Matitiahu
Matok, Ilan
Hamiel, Uri
author_facet Berlin, Maya
Flor-Hirsch, Hadar
Kohn, Elkana
Brik, Anna
Keidar, Rimona
Livne, Ayelet
Marom, Ronella
Ovental, Amit
Mandel, Dror
Lubetzky, Ronit
Factor-Litvak, Pam
Tovbin, Josef
Betser, Moshe
Moskovich, Miki
Hazan, Ariela
Britzi, Malka
Gueta, Itai
Berkovitch, Matitiahu
Matok, Ilan
Hamiel, Uri
author_sort Berlin, Maya
collection PubMed
description Background: Polychlorinated biphenyls (PCBs) are persistent organic pollutants banned for use worldwide. Due to their biodegradation resistance, they accumulate along the food chain and in the environment. Maternal exposure to PCBs may affect the fetus and the infant. PCBs are immunotoxic and may damage the developing immune system. PCBs are associated with elevated IgE antibodies in cord blood and are considered to be predictive of atopic reactions. Several studies on the association between prenatal exposure to PCBs and atopic reactions were previously published, albeit with conflicting results. Objectives: To examine the association between maternal PCBs levels and atopic reactions in their offspring. Methods: During the years 2013–2015, a prospective birth cohort was recruited at the delivery rooms of Shamir Medical Center (Assaf Harofeh) and “Dana Dwek” Children’s Hospital. Four PCBs congeners were investigated: PCBs 118, 138, 153, and 180. In 2019, when children reached the age of 4–6 years, mothers were interviewed using the ISAAC questionnaire to assess symptoms of atopic reactions, including asthma, allergic rhinitis, and atopic dermatitis. Results: One hundred and fifty mother-child dyads were analyzed. No significant differences were found in the median serum PCBs concentrations of each studied congener or total PCBs for asthma, allergic rhinitis, atopic dermatitis diagnosis, or parent-reported symptoms. No association was found between exposure to total PCBs and the risk for asthma symptoms or diagnosis, adjusted to maternal age and family member with atopic condition: aOR = 0.94, 95%CI: (0.88; 0.99). No association was observed between each studied PCB congener and asthma symptoms or diagnosis. The same results were found also for other studied outcomes—allergic rhinitis and atopic dermatitis. Conclusion: Our study joins a series of previous studies that attempt to shed light on environmental exposures in utero as influencing factors for atopic conditions in children. Our results reflect the complexity of the pathophysiology of these phenomena. No relationship between maternal serum PCBs levels was demonstrated for asthma, allergic rhinitis, or atopic dermatitis. However, additional multi-participant studies, with longer, spanning into later pediatric age follow up are needed.
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spelling pubmed-90194722022-04-21 Maternal Exposure to Polychlorinated Biphenyls and Asthma, Allergic Rhinitis and Atopic Dermatitis in the Offspring: The Environmental Health Fund Birth Cohort Berlin, Maya Flor-Hirsch, Hadar Kohn, Elkana Brik, Anna Keidar, Rimona Livne, Ayelet Marom, Ronella Ovental, Amit Mandel, Dror Lubetzky, Ronit Factor-Litvak, Pam Tovbin, Josef Betser, Moshe Moskovich, Miki Hazan, Ariela Britzi, Malka Gueta, Itai Berkovitch, Matitiahu Matok, Ilan Hamiel, Uri Front Pharmacol Pharmacology Background: Polychlorinated biphenyls (PCBs) are persistent organic pollutants banned for use worldwide. Due to their biodegradation resistance, they accumulate along the food chain and in the environment. Maternal exposure to PCBs may affect the fetus and the infant. PCBs are immunotoxic and may damage the developing immune system. PCBs are associated with elevated IgE antibodies in cord blood and are considered to be predictive of atopic reactions. Several studies on the association between prenatal exposure to PCBs and atopic reactions were previously published, albeit with conflicting results. Objectives: To examine the association between maternal PCBs levels and atopic reactions in their offspring. Methods: During the years 2013–2015, a prospective birth cohort was recruited at the delivery rooms of Shamir Medical Center (Assaf Harofeh) and “Dana Dwek” Children’s Hospital. Four PCBs congeners were investigated: PCBs 118, 138, 153, and 180. In 2019, when children reached the age of 4–6 years, mothers were interviewed using the ISAAC questionnaire to assess symptoms of atopic reactions, including asthma, allergic rhinitis, and atopic dermatitis. Results: One hundred and fifty mother-child dyads were analyzed. No significant differences were found in the median serum PCBs concentrations of each studied congener or total PCBs for asthma, allergic rhinitis, atopic dermatitis diagnosis, or parent-reported symptoms. No association was found between exposure to total PCBs and the risk for asthma symptoms or diagnosis, adjusted to maternal age and family member with atopic condition: aOR = 0.94, 95%CI: (0.88; 0.99). No association was observed between each studied PCB congener and asthma symptoms or diagnosis. The same results were found also for other studied outcomes—allergic rhinitis and atopic dermatitis. Conclusion: Our study joins a series of previous studies that attempt to shed light on environmental exposures in utero as influencing factors for atopic conditions in children. Our results reflect the complexity of the pathophysiology of these phenomena. No relationship between maternal serum PCBs levels was demonstrated for asthma, allergic rhinitis, or atopic dermatitis. However, additional multi-participant studies, with longer, spanning into later pediatric age follow up are needed. Frontiers Media S.A. 2022-04-06 /pmc/articles/PMC9019472/ /pubmed/35462915 http://dx.doi.org/10.3389/fphar.2022.802974 Text en Copyright © 2022 Berlin, Flor-Hirsch, Kohn, Brik, Keidar, Livne, Marom, Ovental, Mandel, Lubetzky, Factor-Litvak, Tovbin, Betser, Moskovich, Hazan, Britzi, Gueta, Berkovitch, Matok and Hamiel. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Berlin, Maya
Flor-Hirsch, Hadar
Kohn, Elkana
Brik, Anna
Keidar, Rimona
Livne, Ayelet
Marom, Ronella
Ovental, Amit
Mandel, Dror
Lubetzky, Ronit
Factor-Litvak, Pam
Tovbin, Josef
Betser, Moshe
Moskovich, Miki
Hazan, Ariela
Britzi, Malka
Gueta, Itai
Berkovitch, Matitiahu
Matok, Ilan
Hamiel, Uri
Maternal Exposure to Polychlorinated Biphenyls and Asthma, Allergic Rhinitis and Atopic Dermatitis in the Offspring: The Environmental Health Fund Birth Cohort
title Maternal Exposure to Polychlorinated Biphenyls and Asthma, Allergic Rhinitis and Atopic Dermatitis in the Offspring: The Environmental Health Fund Birth Cohort
title_full Maternal Exposure to Polychlorinated Biphenyls and Asthma, Allergic Rhinitis and Atopic Dermatitis in the Offspring: The Environmental Health Fund Birth Cohort
title_fullStr Maternal Exposure to Polychlorinated Biphenyls and Asthma, Allergic Rhinitis and Atopic Dermatitis in the Offspring: The Environmental Health Fund Birth Cohort
title_full_unstemmed Maternal Exposure to Polychlorinated Biphenyls and Asthma, Allergic Rhinitis and Atopic Dermatitis in the Offspring: The Environmental Health Fund Birth Cohort
title_short Maternal Exposure to Polychlorinated Biphenyls and Asthma, Allergic Rhinitis and Atopic Dermatitis in the Offspring: The Environmental Health Fund Birth Cohort
title_sort maternal exposure to polychlorinated biphenyls and asthma, allergic rhinitis and atopic dermatitis in the offspring: the environmental health fund birth cohort
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019472/
https://www.ncbi.nlm.nih.gov/pubmed/35462915
http://dx.doi.org/10.3389/fphar.2022.802974
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