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miR-874: An Important Regulator in Human Diseases

miR-874 is located at 5q31.2, which is frequently deleted in cancer. miR-874 is downregulated in 22 types of cancers and aberrantly expressed in 18 types of non-cancer diseases. The dysfunction of miR-874 is not only closely related to the diagnosis and prognosis of tumor patients but also plays an...

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Autores principales: Zhang, Qiudan, Zhong, Chenming, Yan, Qianqian, Zeng, Ling-hui, Gao, Wei, Duan, Shiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019486/
https://www.ncbi.nlm.nih.gov/pubmed/35465322
http://dx.doi.org/10.3389/fcell.2022.784968
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author Zhang, Qiudan
Zhong, Chenming
Yan, Qianqian
Zeng, Ling-hui
Gao, Wei
Duan, Shiwei
author_facet Zhang, Qiudan
Zhong, Chenming
Yan, Qianqian
Zeng, Ling-hui
Gao, Wei
Duan, Shiwei
author_sort Zhang, Qiudan
collection PubMed
description miR-874 is located at 5q31.2, which is frequently deleted in cancer. miR-874 is downregulated in 22 types of cancers and aberrantly expressed in 18 types of non-cancer diseases. The dysfunction of miR-874 is not only closely related to the diagnosis and prognosis of tumor patients but also plays an important role in the efficacy of tumor chemotherapy drugs. miR-874 participates in the ceRNA network of long non-coding RNAs or circular RNAs, which is closely related to the occurrence and development of cancer and other non-cancer diseases. In addition, miR-874 is also involved in the regulation of multiple signaling pathways, including the Wnt/β-catenin signaling pathway, Hippo signaling pathway, PI3K/AKT signaling pathway, JAK/STAT signaling pathway, and Hedgehog signaling pathway. This review summarizes the molecular functions of miR-874 in the biological processes of tumor cell survival, apoptosis, differentiation, and tumorigenesis, and reveal the value of miR-874 as a cancer biomarker in tumor diagnosis and prognosis. Future work is necessary to explore the potential clinical application of miR-874 in chemotherapy resistance.
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spelling pubmed-90194862022-04-21 miR-874: An Important Regulator in Human Diseases Zhang, Qiudan Zhong, Chenming Yan, Qianqian Zeng, Ling-hui Gao, Wei Duan, Shiwei Front Cell Dev Biol Cell and Developmental Biology miR-874 is located at 5q31.2, which is frequently deleted in cancer. miR-874 is downregulated in 22 types of cancers and aberrantly expressed in 18 types of non-cancer diseases. The dysfunction of miR-874 is not only closely related to the diagnosis and prognosis of tumor patients but also plays an important role in the efficacy of tumor chemotherapy drugs. miR-874 participates in the ceRNA network of long non-coding RNAs or circular RNAs, which is closely related to the occurrence and development of cancer and other non-cancer diseases. In addition, miR-874 is also involved in the regulation of multiple signaling pathways, including the Wnt/β-catenin signaling pathway, Hippo signaling pathway, PI3K/AKT signaling pathway, JAK/STAT signaling pathway, and Hedgehog signaling pathway. This review summarizes the molecular functions of miR-874 in the biological processes of tumor cell survival, apoptosis, differentiation, and tumorigenesis, and reveal the value of miR-874 as a cancer biomarker in tumor diagnosis and prognosis. Future work is necessary to explore the potential clinical application of miR-874 in chemotherapy resistance. Frontiers Media S.A. 2022-04-06 /pmc/articles/PMC9019486/ /pubmed/35465322 http://dx.doi.org/10.3389/fcell.2022.784968 Text en Copyright © 2022 Zhang, Zhong, Yan, Zeng, Gao and Duan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Zhang, Qiudan
Zhong, Chenming
Yan, Qianqian
Zeng, Ling-hui
Gao, Wei
Duan, Shiwei
miR-874: An Important Regulator in Human Diseases
title miR-874: An Important Regulator in Human Diseases
title_full miR-874: An Important Regulator in Human Diseases
title_fullStr miR-874: An Important Regulator in Human Diseases
title_full_unstemmed miR-874: An Important Regulator in Human Diseases
title_short miR-874: An Important Regulator in Human Diseases
title_sort mir-874: an important regulator in human diseases
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019486/
https://www.ncbi.nlm.nih.gov/pubmed/35465322
http://dx.doi.org/10.3389/fcell.2022.784968
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