Cargando…
The Role of NcRNAs to Regulate Immune Checkpoints in Cancer
At present, the incidence of cancer is becoming more and more common, but its treatment has always been a problem. Although a small number of cancers can be treated, the recurrence rates are generally high and cannot be completely cured. At present, conventional cancer therapies mainly include chemo...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019622/ https://www.ncbi.nlm.nih.gov/pubmed/35464451 http://dx.doi.org/10.3389/fimmu.2022.853480 |
_version_ | 1784689329420894208 |
---|---|
author | Jiang, Yicun Zhao, Leilei Wu, Yiwen Deng, Sijun Cao, Pu Lei, Xiaoyong Yang, Xiaoyan |
author_facet | Jiang, Yicun Zhao, Leilei Wu, Yiwen Deng, Sijun Cao, Pu Lei, Xiaoyong Yang, Xiaoyan |
author_sort | Jiang, Yicun |
collection | PubMed |
description | At present, the incidence of cancer is becoming more and more common, but its treatment has always been a problem. Although a small number of cancers can be treated, the recurrence rates are generally high and cannot be completely cured. At present, conventional cancer therapies mainly include chemotherapy and radiotherapy, which are the first-line therapies for most cancer patients, but there are palliatives. Approaches to cancer treatment are not as fast as cancer development. The current cancer treatments have not been effective in stopping the development of cancer, and cancer treatment needs to be imported into new strategies. Non-coding RNAs (ncRNAs) is a hot research topic at present. NcRNAs, which include microRNAs (miRNAs), circular RNAs (circRNAs), and long non-coding RNAs (lncRNAs), participate in all aspects of cancer biology. They are involved in the progression of tumors into a new form, including B-cell lymphoma, glioma, or the parenchymal tumors such as gastric cancer and colon cancer, among others. NcRNAs target various immune checkpoints to affect tumor proliferation, differentiation, and development. This might represent a new strategy for cancer treatment. |
format | Online Article Text |
id | pubmed-9019622 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90196222022-04-21 The Role of NcRNAs to Regulate Immune Checkpoints in Cancer Jiang, Yicun Zhao, Leilei Wu, Yiwen Deng, Sijun Cao, Pu Lei, Xiaoyong Yang, Xiaoyan Front Immunol Immunology At present, the incidence of cancer is becoming more and more common, but its treatment has always been a problem. Although a small number of cancers can be treated, the recurrence rates are generally high and cannot be completely cured. At present, conventional cancer therapies mainly include chemotherapy and radiotherapy, which are the first-line therapies for most cancer patients, but there are palliatives. Approaches to cancer treatment are not as fast as cancer development. The current cancer treatments have not been effective in stopping the development of cancer, and cancer treatment needs to be imported into new strategies. Non-coding RNAs (ncRNAs) is a hot research topic at present. NcRNAs, which include microRNAs (miRNAs), circular RNAs (circRNAs), and long non-coding RNAs (lncRNAs), participate in all aspects of cancer biology. They are involved in the progression of tumors into a new form, including B-cell lymphoma, glioma, or the parenchymal tumors such as gastric cancer and colon cancer, among others. NcRNAs target various immune checkpoints to affect tumor proliferation, differentiation, and development. This might represent a new strategy for cancer treatment. Frontiers Media S.A. 2022-04-06 /pmc/articles/PMC9019622/ /pubmed/35464451 http://dx.doi.org/10.3389/fimmu.2022.853480 Text en Copyright © 2022 Jiang, Zhao, Wu, Deng, Cao, Lei and Yang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Jiang, Yicun Zhao, Leilei Wu, Yiwen Deng, Sijun Cao, Pu Lei, Xiaoyong Yang, Xiaoyan The Role of NcRNAs to Regulate Immune Checkpoints in Cancer |
title | The Role of NcRNAs to Regulate Immune Checkpoints in Cancer |
title_full | The Role of NcRNAs to Regulate Immune Checkpoints in Cancer |
title_fullStr | The Role of NcRNAs to Regulate Immune Checkpoints in Cancer |
title_full_unstemmed | The Role of NcRNAs to Regulate Immune Checkpoints in Cancer |
title_short | The Role of NcRNAs to Regulate Immune Checkpoints in Cancer |
title_sort | role of ncrnas to regulate immune checkpoints in cancer |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019622/ https://www.ncbi.nlm.nih.gov/pubmed/35464451 http://dx.doi.org/10.3389/fimmu.2022.853480 |
work_keys_str_mv | AT jiangyicun theroleofncrnastoregulateimmunecheckpointsincancer AT zhaoleilei theroleofncrnastoregulateimmunecheckpointsincancer AT wuyiwen theroleofncrnastoregulateimmunecheckpointsincancer AT dengsijun theroleofncrnastoregulateimmunecheckpointsincancer AT caopu theroleofncrnastoregulateimmunecheckpointsincancer AT leixiaoyong theroleofncrnastoregulateimmunecheckpointsincancer AT yangxiaoyan theroleofncrnastoregulateimmunecheckpointsincancer AT jiangyicun roleofncrnastoregulateimmunecheckpointsincancer AT zhaoleilei roleofncrnastoregulateimmunecheckpointsincancer AT wuyiwen roleofncrnastoregulateimmunecheckpointsincancer AT dengsijun roleofncrnastoregulateimmunecheckpointsincancer AT caopu roleofncrnastoregulateimmunecheckpointsincancer AT leixiaoyong roleofncrnastoregulateimmunecheckpointsincancer AT yangxiaoyan roleofncrnastoregulateimmunecheckpointsincancer |