Cargando…
Immunological signature of chronic spontaneous urticaria (Review)
Chronic urticaria (CU) is a condition characterized by intensely pruritic, edematous, erythematous papules lasting for more than 6 weeks. Over half of the cases have concomitant swelling of deeper tissues, known as angioedema. The socio-economic burden of the disease is significant. Unfortunately, p...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019689/ https://www.ncbi.nlm.nih.gov/pubmed/35495604 http://dx.doi.org/10.3892/etm.2022.11309 |
_version_ | 1784689347179577344 |
---|---|
author | Dobrican, Carmen-Teodora Muntean, Ioana Adriana Pintea, Irena Petricău, Carina Deleanu, Diana-Mihaela Filip, Gabriela Adriana |
author_facet | Dobrican, Carmen-Teodora Muntean, Ioana Adriana Pintea, Irena Petricău, Carina Deleanu, Diana-Mihaela Filip, Gabriela Adriana |
author_sort | Dobrican, Carmen-Teodora |
collection | PubMed |
description | Chronic urticaria (CU) is a condition characterized by intensely pruritic, edematous, erythematous papules lasting for more than 6 weeks. Over half of the cases have concomitant swelling of deeper tissues, known as angioedema. The socio-economic burden of the disease is significant. Unfortunately, patients with severe CU, refractory to conventional treatment, have limited and expensive therapeutic options. The pathogenesis of CU is not yet completely understood. Therefore, elucidating the pathophysiological mechanisms involved would potentially identify new therapeutic targets. It has been accepted in recent years that mast cells and their activation, followed by excessive degranulation represent the key pathophysiological events in chronic spontaneous urticaria (CSU). The triggering events and the complexity of the effector mechanisms, however, remain intensely debated topics with conflicting studies. One pathogenetic mechanism incriminated in chronic spontaneous urticaria is the response mediated by the high-affinity receptor for IgE (FcεRI) expressed on mast cells. Increasing recognition of chronic spontaneous urticaria as an autoimmune disease linked to the cytokine-chemokine network imbalance resulting from alteration of innate immune response is another pathogenetic explanation. It is likely that these different pathological mechanisms are more interconnected, both acting synergistically, rather than separately, to produce the clinical expression of CU. The discovery and understanding of pathogenic mechanisms represent the premise for the development of safe and effective immunomodulators and targeted biological treatment for severe, refractory CU. |
format | Online Article Text |
id | pubmed-9019689 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-90196892022-04-27 Immunological signature of chronic spontaneous urticaria (Review) Dobrican, Carmen-Teodora Muntean, Ioana Adriana Pintea, Irena Petricău, Carina Deleanu, Diana-Mihaela Filip, Gabriela Adriana Exp Ther Med Review Chronic urticaria (CU) is a condition characterized by intensely pruritic, edematous, erythematous papules lasting for more than 6 weeks. Over half of the cases have concomitant swelling of deeper tissues, known as angioedema. The socio-economic burden of the disease is significant. Unfortunately, patients with severe CU, refractory to conventional treatment, have limited and expensive therapeutic options. The pathogenesis of CU is not yet completely understood. Therefore, elucidating the pathophysiological mechanisms involved would potentially identify new therapeutic targets. It has been accepted in recent years that mast cells and their activation, followed by excessive degranulation represent the key pathophysiological events in chronic spontaneous urticaria (CSU). The triggering events and the complexity of the effector mechanisms, however, remain intensely debated topics with conflicting studies. One pathogenetic mechanism incriminated in chronic spontaneous urticaria is the response mediated by the high-affinity receptor for IgE (FcεRI) expressed on mast cells. Increasing recognition of chronic spontaneous urticaria as an autoimmune disease linked to the cytokine-chemokine network imbalance resulting from alteration of innate immune response is another pathogenetic explanation. It is likely that these different pathological mechanisms are more interconnected, both acting synergistically, rather than separately, to produce the clinical expression of CU. The discovery and understanding of pathogenic mechanisms represent the premise for the development of safe and effective immunomodulators and targeted biological treatment for severe, refractory CU. D.A. Spandidos 2022-06 2022-04-08 /pmc/articles/PMC9019689/ /pubmed/35495604 http://dx.doi.org/10.3892/etm.2022.11309 Text en Copyright: © Dobrican et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Review Dobrican, Carmen-Teodora Muntean, Ioana Adriana Pintea, Irena Petricău, Carina Deleanu, Diana-Mihaela Filip, Gabriela Adriana Immunological signature of chronic spontaneous urticaria (Review) |
title | Immunological signature of chronic spontaneous urticaria (Review) |
title_full | Immunological signature of chronic spontaneous urticaria (Review) |
title_fullStr | Immunological signature of chronic spontaneous urticaria (Review) |
title_full_unstemmed | Immunological signature of chronic spontaneous urticaria (Review) |
title_short | Immunological signature of chronic spontaneous urticaria (Review) |
title_sort | immunological signature of chronic spontaneous urticaria (review) |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019689/ https://www.ncbi.nlm.nih.gov/pubmed/35495604 http://dx.doi.org/10.3892/etm.2022.11309 |
work_keys_str_mv | AT dobricancarmenteodora immunologicalsignatureofchronicspontaneousurticariareview AT munteanioanaadriana immunologicalsignatureofchronicspontaneousurticariareview AT pinteairena immunologicalsignatureofchronicspontaneousurticariareview AT petricaucarina immunologicalsignatureofchronicspontaneousurticariareview AT deleanudianamihaela immunologicalsignatureofchronicspontaneousurticariareview AT filipgabrielaadriana immunologicalsignatureofchronicspontaneousurticariareview |