Dietary Nutrition and Gut Microbiota Composition in Patients With Hypertensive Disorders of Pregnancy

OBJECTIVE: The aim is to explore the intakes of dietary nutrients and the changes of gut microbiota composition among patients with hypertensive disorders of pregnancy (HDP) and provide a theoretical basis for the prevention and treatment of HDP. METHODS: This study was conducted at the Maternal and...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Jinran, Zhang, Bo, Miao, Tingting, Hu, Haiting, Sun, Yongye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019690/
https://www.ncbi.nlm.nih.gov/pubmed/35464021
http://dx.doi.org/10.3389/fnut.2022.862892
_version_ 1784689347410264064
author Yu, Jinran
Zhang, Bo
Miao, Tingting
Hu, Haiting
Sun, Yongye
author_facet Yu, Jinran
Zhang, Bo
Miao, Tingting
Hu, Haiting
Sun, Yongye
author_sort Yu, Jinran
collection PubMed
description OBJECTIVE: The aim is to explore the intakes of dietary nutrients and the changes of gut microbiota composition among patients with hypertensive disorders of pregnancy (HDP) and provide a theoretical basis for the prevention and treatment of HDP. METHODS: This study was conducted at the Maternal and Child Health Care Hospital of Changzhou. A total of 170 pregnant women (72 patients with HDP in the case group and 98 healthy pregnant women in the control group) in the third trimester were enrolled. Dietary nutrient intakes were assessed through a food frequency questionnaire survey. Fresh fecal samples were aseptically collected, and 16S rDNA sequencing was conducted. The intakes of dietary nutrients and the diversity and relative abundance of gut microbiota were compared between pregnant women with and without HDP. A logistic regression model was used to investigate the association between differential gut microbial genera and the risk of HDP. RESULTS: The daily dietary intakes of vitamin A and vitamin C in pregnant women with HDP were significantly lower than those in the control group. The relative abundances of Bacteroidota, Bacteroidaceae, and Bacteroides were increased, and the relative abundances of Actinobacteriota, Lachnospiraceae, Prevotellaceae, Bifidobacteriaceae, Blautia, Prevotella, and Bifidobacterium were decreased in women with HDP compared with those in the controls. In addition, the relative abundance of Bifidobacterium was positively correlated with dietary intakes of vitamin C and vitamin E in patients with HDP. After adjustment for confounding factors, the odds ratio (95% confidence interval) of HDP for the relative abundance of Bifidobacterium was 0.899 (0.813, 0.995). CONCLUSION: The composition of gut microbiota in pregnant women with HDP was significantly changed compared with that of healthy controls. The relative abundance of Bifidobacterium was negatively associated with HDP. Moreover, dietary vitamin C and gut Bifidobacterium may cooperatively contribute to reduce the risk of HDP.
format Online
Article
Text
id pubmed-9019690
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-90196902022-04-21 Dietary Nutrition and Gut Microbiota Composition in Patients With Hypertensive Disorders of Pregnancy Yu, Jinran Zhang, Bo Miao, Tingting Hu, Haiting Sun, Yongye Front Nutr Nutrition OBJECTIVE: The aim is to explore the intakes of dietary nutrients and the changes of gut microbiota composition among patients with hypertensive disorders of pregnancy (HDP) and provide a theoretical basis for the prevention and treatment of HDP. METHODS: This study was conducted at the Maternal and Child Health Care Hospital of Changzhou. A total of 170 pregnant women (72 patients with HDP in the case group and 98 healthy pregnant women in the control group) in the third trimester were enrolled. Dietary nutrient intakes were assessed through a food frequency questionnaire survey. Fresh fecal samples were aseptically collected, and 16S rDNA sequencing was conducted. The intakes of dietary nutrients and the diversity and relative abundance of gut microbiota were compared between pregnant women with and without HDP. A logistic regression model was used to investigate the association between differential gut microbial genera and the risk of HDP. RESULTS: The daily dietary intakes of vitamin A and vitamin C in pregnant women with HDP were significantly lower than those in the control group. The relative abundances of Bacteroidota, Bacteroidaceae, and Bacteroides were increased, and the relative abundances of Actinobacteriota, Lachnospiraceae, Prevotellaceae, Bifidobacteriaceae, Blautia, Prevotella, and Bifidobacterium were decreased in women with HDP compared with those in the controls. In addition, the relative abundance of Bifidobacterium was positively correlated with dietary intakes of vitamin C and vitamin E in patients with HDP. After adjustment for confounding factors, the odds ratio (95% confidence interval) of HDP for the relative abundance of Bifidobacterium was 0.899 (0.813, 0.995). CONCLUSION: The composition of gut microbiota in pregnant women with HDP was significantly changed compared with that of healthy controls. The relative abundance of Bifidobacterium was negatively associated with HDP. Moreover, dietary vitamin C and gut Bifidobacterium may cooperatively contribute to reduce the risk of HDP. Frontiers Media S.A. 2022-04-06 /pmc/articles/PMC9019690/ /pubmed/35464021 http://dx.doi.org/10.3389/fnut.2022.862892 Text en Copyright © 2022 Yu, Zhang, Miao, Hu and Sun. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Yu, Jinran
Zhang, Bo
Miao, Tingting
Hu, Haiting
Sun, Yongye
Dietary Nutrition and Gut Microbiota Composition in Patients With Hypertensive Disorders of Pregnancy
title Dietary Nutrition and Gut Microbiota Composition in Patients With Hypertensive Disorders of Pregnancy
title_full Dietary Nutrition and Gut Microbiota Composition in Patients With Hypertensive Disorders of Pregnancy
title_fullStr Dietary Nutrition and Gut Microbiota Composition in Patients With Hypertensive Disorders of Pregnancy
title_full_unstemmed Dietary Nutrition and Gut Microbiota Composition in Patients With Hypertensive Disorders of Pregnancy
title_short Dietary Nutrition and Gut Microbiota Composition in Patients With Hypertensive Disorders of Pregnancy
title_sort dietary nutrition and gut microbiota composition in patients with hypertensive disorders of pregnancy
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019690/
https://www.ncbi.nlm.nih.gov/pubmed/35464021
http://dx.doi.org/10.3389/fnut.2022.862892
work_keys_str_mv AT yujinran dietarynutritionandgutmicrobiotacompositioninpatientswithhypertensivedisordersofpregnancy
AT zhangbo dietarynutritionandgutmicrobiotacompositioninpatientswithhypertensivedisordersofpregnancy
AT miaotingting dietarynutritionandgutmicrobiotacompositioninpatientswithhypertensivedisordersofpregnancy
AT huhaiting dietarynutritionandgutmicrobiotacompositioninpatientswithhypertensivedisordersofpregnancy
AT sunyongye dietarynutritionandgutmicrobiotacompositioninpatientswithhypertensivedisordersofpregnancy