Single Stranded Fully Modified-Phosphorothioate Oligonucleotides can Induce Structured Nuclear Inclusions, Alter Nuclear Protein Localization and Disturb the Transcriptome In Vitro

Oligonucleotides and nucleic acid analogues that alter gene expression are now showing therapeutic promise in human disease. Whilst the modification of synthetic nucleic acids to protect against nuclease degradation and to influence drug function is common practice, such modifications may also confe...

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Detalles Bibliográficos
Autores principales: Flynn, Loren L., Li, Ruohan, Pitout, Ianthe L., Aung-Htut, May T., Larcher, Leon M., Cooper, Jack A. L., Greer, Kane L., Hubbard, Alysia, Griffiths, Lisa, Bond, Charles S., Wilton, Steve D., Fox, Archa H., Fletcher, Sue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019733/
https://www.ncbi.nlm.nih.gov/pubmed/35464859
http://dx.doi.org/10.3389/fgene.2022.791416

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