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The Role of Flavonoids in the Osteogenic Differentiation of Mesenchymal Stem Cells
Mesenchymal stem cells (MSCs) play an important role in developing bone tissue engineered constructs due to their osteogenic and chondrogenic differentiation potential. MSC-based tissue engineered constructs are generally considered a safe procedure, however, the long-term results obtained up to now...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019748/ https://www.ncbi.nlm.nih.gov/pubmed/35462886 http://dx.doi.org/10.3389/fphar.2022.849513 |
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author | Zhang, Jinli Liu, Zhihe Luo, Yang Li, Xiaojian Huang, Guowei Chen, Huan Li, Aiguo Qin, Shengnan |
author_facet | Zhang, Jinli Liu, Zhihe Luo, Yang Li, Xiaojian Huang, Guowei Chen, Huan Li, Aiguo Qin, Shengnan |
author_sort | Zhang, Jinli |
collection | PubMed |
description | Mesenchymal stem cells (MSCs) play an important role in developing bone tissue engineered constructs due to their osteogenic and chondrogenic differentiation potential. MSC-based tissue engineered constructs are generally considered a safe procedure, however, the long-term results obtained up to now are far from satisfactory. The main causes of these therapeutic limitations are inefficient homing, engraftment, and directional differentiation. Flavonoids are a secondary metabolite, widely existed in nature and have many biological activities. For a long time, researchers have confirmed the anti-osteoporosis effect of flavonoids through in vitro cell experiments, animal studies. In recent years the regulatory effects of flavonoids on mesenchymal stem cells (MSCs) differentiation have been received increasingly attention. Recent studies revealed flavonoids possess the ability to modulate self-renewal and differentiation potential of MSCs. In order to facilitate further research on MSCs osteogenic differentiation of flavonoids, we surveyed the literature published on the use of flavonoids in osteogenic differentiation of MSCs, and summarized their pharmacological activities as well as the underlying mechanisms, aimed to explore their promising therapeutic application in bone disorders and bone tissue engineered constructs. |
format | Online Article Text |
id | pubmed-9019748 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90197482022-04-21 The Role of Flavonoids in the Osteogenic Differentiation of Mesenchymal Stem Cells Zhang, Jinli Liu, Zhihe Luo, Yang Li, Xiaojian Huang, Guowei Chen, Huan Li, Aiguo Qin, Shengnan Front Pharmacol Pharmacology Mesenchymal stem cells (MSCs) play an important role in developing bone tissue engineered constructs due to their osteogenic and chondrogenic differentiation potential. MSC-based tissue engineered constructs are generally considered a safe procedure, however, the long-term results obtained up to now are far from satisfactory. The main causes of these therapeutic limitations are inefficient homing, engraftment, and directional differentiation. Flavonoids are a secondary metabolite, widely existed in nature and have many biological activities. For a long time, researchers have confirmed the anti-osteoporosis effect of flavonoids through in vitro cell experiments, animal studies. In recent years the regulatory effects of flavonoids on mesenchymal stem cells (MSCs) differentiation have been received increasingly attention. Recent studies revealed flavonoids possess the ability to modulate self-renewal and differentiation potential of MSCs. In order to facilitate further research on MSCs osteogenic differentiation of flavonoids, we surveyed the literature published on the use of flavonoids in osteogenic differentiation of MSCs, and summarized their pharmacological activities as well as the underlying mechanisms, aimed to explore their promising therapeutic application in bone disorders and bone tissue engineered constructs. Frontiers Media S.A. 2022-04-06 /pmc/articles/PMC9019748/ /pubmed/35462886 http://dx.doi.org/10.3389/fphar.2022.849513 Text en Copyright © 2022 Zhang, Liu, Luo, Li, Huang, Chen, Li and Qin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Zhang, Jinli Liu, Zhihe Luo, Yang Li, Xiaojian Huang, Guowei Chen, Huan Li, Aiguo Qin, Shengnan The Role of Flavonoids in the Osteogenic Differentiation of Mesenchymal Stem Cells |
title | The Role of Flavonoids in the Osteogenic Differentiation of Mesenchymal Stem Cells |
title_full | The Role of Flavonoids in the Osteogenic Differentiation of Mesenchymal Stem Cells |
title_fullStr | The Role of Flavonoids in the Osteogenic Differentiation of Mesenchymal Stem Cells |
title_full_unstemmed | The Role of Flavonoids in the Osteogenic Differentiation of Mesenchymal Stem Cells |
title_short | The Role of Flavonoids in the Osteogenic Differentiation of Mesenchymal Stem Cells |
title_sort | role of flavonoids in the osteogenic differentiation of mesenchymal stem cells |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019748/ https://www.ncbi.nlm.nih.gov/pubmed/35462886 http://dx.doi.org/10.3389/fphar.2022.849513 |
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