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The Role of Flavonoids in the Osteogenic Differentiation of Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) play an important role in developing bone tissue engineered constructs due to their osteogenic and chondrogenic differentiation potential. MSC-based tissue engineered constructs are generally considered a safe procedure, however, the long-term results obtained up to now...

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Autores principales: Zhang, Jinli, Liu, Zhihe, Luo, Yang, Li, Xiaojian, Huang, Guowei, Chen, Huan, Li, Aiguo, Qin, Shengnan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019748/
https://www.ncbi.nlm.nih.gov/pubmed/35462886
http://dx.doi.org/10.3389/fphar.2022.849513
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author Zhang, Jinli
Liu, Zhihe
Luo, Yang
Li, Xiaojian
Huang, Guowei
Chen, Huan
Li, Aiguo
Qin, Shengnan
author_facet Zhang, Jinli
Liu, Zhihe
Luo, Yang
Li, Xiaojian
Huang, Guowei
Chen, Huan
Li, Aiguo
Qin, Shengnan
author_sort Zhang, Jinli
collection PubMed
description Mesenchymal stem cells (MSCs) play an important role in developing bone tissue engineered constructs due to their osteogenic and chondrogenic differentiation potential. MSC-based tissue engineered constructs are generally considered a safe procedure, however, the long-term results obtained up to now are far from satisfactory. The main causes of these therapeutic limitations are inefficient homing, engraftment, and directional differentiation. Flavonoids are a secondary metabolite, widely existed in nature and have many biological activities. For a long time, researchers have confirmed the anti-osteoporosis effect of flavonoids through in vitro cell experiments, animal studies. In recent years the regulatory effects of flavonoids on mesenchymal stem cells (MSCs) differentiation have been received increasingly attention. Recent studies revealed flavonoids possess the ability to modulate self-renewal and differentiation potential of MSCs. In order to facilitate further research on MSCs osteogenic differentiation of flavonoids, we surveyed the literature published on the use of flavonoids in osteogenic differentiation of MSCs, and summarized their pharmacological activities as well as the underlying mechanisms, aimed to explore their promising therapeutic application in bone disorders and bone tissue engineered constructs.
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spelling pubmed-90197482022-04-21 The Role of Flavonoids in the Osteogenic Differentiation of Mesenchymal Stem Cells Zhang, Jinli Liu, Zhihe Luo, Yang Li, Xiaojian Huang, Guowei Chen, Huan Li, Aiguo Qin, Shengnan Front Pharmacol Pharmacology Mesenchymal stem cells (MSCs) play an important role in developing bone tissue engineered constructs due to their osteogenic and chondrogenic differentiation potential. MSC-based tissue engineered constructs are generally considered a safe procedure, however, the long-term results obtained up to now are far from satisfactory. The main causes of these therapeutic limitations are inefficient homing, engraftment, and directional differentiation. Flavonoids are a secondary metabolite, widely existed in nature and have many biological activities. For a long time, researchers have confirmed the anti-osteoporosis effect of flavonoids through in vitro cell experiments, animal studies. In recent years the regulatory effects of flavonoids on mesenchymal stem cells (MSCs) differentiation have been received increasingly attention. Recent studies revealed flavonoids possess the ability to modulate self-renewal and differentiation potential of MSCs. In order to facilitate further research on MSCs osteogenic differentiation of flavonoids, we surveyed the literature published on the use of flavonoids in osteogenic differentiation of MSCs, and summarized their pharmacological activities as well as the underlying mechanisms, aimed to explore their promising therapeutic application in bone disorders and bone tissue engineered constructs. Frontiers Media S.A. 2022-04-06 /pmc/articles/PMC9019748/ /pubmed/35462886 http://dx.doi.org/10.3389/fphar.2022.849513 Text en Copyright © 2022 Zhang, Liu, Luo, Li, Huang, Chen, Li and Qin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Zhang, Jinli
Liu, Zhihe
Luo, Yang
Li, Xiaojian
Huang, Guowei
Chen, Huan
Li, Aiguo
Qin, Shengnan
The Role of Flavonoids in the Osteogenic Differentiation of Mesenchymal Stem Cells
title The Role of Flavonoids in the Osteogenic Differentiation of Mesenchymal Stem Cells
title_full The Role of Flavonoids in the Osteogenic Differentiation of Mesenchymal Stem Cells
title_fullStr The Role of Flavonoids in the Osteogenic Differentiation of Mesenchymal Stem Cells
title_full_unstemmed The Role of Flavonoids in the Osteogenic Differentiation of Mesenchymal Stem Cells
title_short The Role of Flavonoids in the Osteogenic Differentiation of Mesenchymal Stem Cells
title_sort role of flavonoids in the osteogenic differentiation of mesenchymal stem cells
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019748/
https://www.ncbi.nlm.nih.gov/pubmed/35462886
http://dx.doi.org/10.3389/fphar.2022.849513
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