Latent Variables Capture Pathway-Level Points of Departure in High-Throughput Toxicogenomic Data

[Image: see text] Estimation of points of departure (PoDs) from high-throughput transcriptomic data (HTTr) represents a key step in the development of next-generation risk assessment (NGRA). Current approaches mainly rely on single key gene targets, which are constrained by the information currently...

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Detalles Bibliográficos
Autores principales: Basili, Danilo, Reynolds, Joe, Houghton, Jade, Malcomber, Sophie, Chambers, Bryant, Liddell, Mark, Muller, Iris, White, Andrew, Shah, Imran, Everett, Logan J., Middleton, Alistair, Bender, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019810/
https://www.ncbi.nlm.nih.gov/pubmed/35333521
http://dx.doi.org/10.1021/acs.chemrestox.1c00444

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