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Clinical significance of FAT1 gene mutation and mRNA expression in patients with head and neck squamous cell carcinoma

The FAT1 gene functions as a tumor suppressor or promoter and remains incompletely understood. We examined the clinical significance of FAT1 in head and neck squamous cell carcinoma (HNSCC) using four publicly available HNSCC cohorts and one HNSCC cohort enrolled at a tertiary medical center. We dev...

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Autores principales: Kim, Su Il, Woo, Seon Rang, Noh, Joo Kyung, Lee, Min Kyeong, Lee, Young Chan, Lee, Jung Woo, Ko, Seong‐Gyu, Eun, Young‐Gyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019907/
https://www.ncbi.nlm.nih.gov/pubmed/34939311
http://dx.doi.org/10.1002/1878-0261.13171
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author Kim, Su Il
Woo, Seon Rang
Noh, Joo Kyung
Lee, Min Kyeong
Lee, Young Chan
Lee, Jung Woo
Ko, Seong‐Gyu
Eun, Young‐Gyu
author_facet Kim, Su Il
Woo, Seon Rang
Noh, Joo Kyung
Lee, Min Kyeong
Lee, Young Chan
Lee, Jung Woo
Ko, Seong‐Gyu
Eun, Young‐Gyu
author_sort Kim, Su Il
collection PubMed
description The FAT1 gene functions as a tumor suppressor or promoter and remains incompletely understood. We examined the clinical significance of FAT1 in head and neck squamous cell carcinoma (HNSCC) using four publicly available HNSCC cohorts and one HNSCC cohort enrolled at a tertiary medical center. We developed FAT1 signatures reflecting FAT1 mutations and mRNA expression using one cohort. Patients with HNSCC were classified into FAT1‐associated low risk (FAT1‐LR; n = 195) and FAT1‐associated high risk (FAT1‐HR; n = 371) subgroups. The five‐year overall survival and recurrence‐free survival rates were significantly lower in the FAT1‐HR subgroup than in the FAT1‐LR subgroup (P = 0.01 and 0.003, respectively). The clinical significance of FAT1 was validated using four independent cohorts. Cox proportional hazards models showed that the FAT1 signature was an independent prognostic factor for HNSCC patients. In addition, FAT1 signature was associated with the response to radiotherapy, advanced stage, and human papilloma virus (HPV) status in HNSCC patients. In conclusion, the FAT1 gene signature was associated with prognosis of HNSCC and may help to provide personalized treatments for HNSCC patients.
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spelling pubmed-90199072022-04-25 Clinical significance of FAT1 gene mutation and mRNA expression in patients with head and neck squamous cell carcinoma Kim, Su Il Woo, Seon Rang Noh, Joo Kyung Lee, Min Kyeong Lee, Young Chan Lee, Jung Woo Ko, Seong‐Gyu Eun, Young‐Gyu Mol Oncol Research Articles The FAT1 gene functions as a tumor suppressor or promoter and remains incompletely understood. We examined the clinical significance of FAT1 in head and neck squamous cell carcinoma (HNSCC) using four publicly available HNSCC cohorts and one HNSCC cohort enrolled at a tertiary medical center. We developed FAT1 signatures reflecting FAT1 mutations and mRNA expression using one cohort. Patients with HNSCC were classified into FAT1‐associated low risk (FAT1‐LR; n = 195) and FAT1‐associated high risk (FAT1‐HR; n = 371) subgroups. The five‐year overall survival and recurrence‐free survival rates were significantly lower in the FAT1‐HR subgroup than in the FAT1‐LR subgroup (P = 0.01 and 0.003, respectively). The clinical significance of FAT1 was validated using four independent cohorts. Cox proportional hazards models showed that the FAT1 signature was an independent prognostic factor for HNSCC patients. In addition, FAT1 signature was associated with the response to radiotherapy, advanced stage, and human papilloma virus (HPV) status in HNSCC patients. In conclusion, the FAT1 gene signature was associated with prognosis of HNSCC and may help to provide personalized treatments for HNSCC patients. John Wiley and Sons Inc. 2022-01-13 2022-04 /pmc/articles/PMC9019907/ /pubmed/34939311 http://dx.doi.org/10.1002/1878-0261.13171 Text en © 2021 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Kim, Su Il
Woo, Seon Rang
Noh, Joo Kyung
Lee, Min Kyeong
Lee, Young Chan
Lee, Jung Woo
Ko, Seong‐Gyu
Eun, Young‐Gyu
Clinical significance of FAT1 gene mutation and mRNA expression in patients with head and neck squamous cell carcinoma
title Clinical significance of FAT1 gene mutation and mRNA expression in patients with head and neck squamous cell carcinoma
title_full Clinical significance of FAT1 gene mutation and mRNA expression in patients with head and neck squamous cell carcinoma
title_fullStr Clinical significance of FAT1 gene mutation and mRNA expression in patients with head and neck squamous cell carcinoma
title_full_unstemmed Clinical significance of FAT1 gene mutation and mRNA expression in patients with head and neck squamous cell carcinoma
title_short Clinical significance of FAT1 gene mutation and mRNA expression in patients with head and neck squamous cell carcinoma
title_sort clinical significance of fat1 gene mutation and mrna expression in patients with head and neck squamous cell carcinoma
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019907/
https://www.ncbi.nlm.nih.gov/pubmed/34939311
http://dx.doi.org/10.1002/1878-0261.13171
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