Discovery of a novel SHIP1 agonist that promotes degradation of lipid-laden phagocytic cargo by microglia

Here, we describe the use of artificial intelligence to identify novel agonists of the SH2-containing 5′ inositol phosphatase 1 (SHIP1). One of the compounds, K306, represents the most potent agonist identified to date. We find that K306 exhibits selectivity for SHIP1 vs. the paralog enzyme SHIP2, a...

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Detalles Bibliográficos
Autores principales: Pedicone, Chiara, Fernandes, Sandra, Matera, Alessandro, Meyer, Shea T., Loh, Stewart, Ha, Jeung-Hoi, Bernard, Denzil, Chisholm, John D., Paolicelli, Rosa Chiara, Kerr, William G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020084/
https://www.ncbi.nlm.nih.gov/pubmed/35465359
http://dx.doi.org/10.1016/j.isci.2022.104170

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