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Combination Blockade of the IL6R/STAT-3 Axis with TIGIT and Its Impact on the Functional Activity of NK Cells against Prostate Cancer Cells

METHODS: We analyzed the secretion of cytokines, chemokines, and growth factors in 22Rv1, LNCaP, and DU145 cells. In these cells, we also evaluated the expression of NK ligands, IL6R, STAT-3, and phosporylated STAT-3. In NK-92 cells, we evaluated the effects of Stattic (Stt) and tocilizumab (Tcz) on...

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Detalles Bibliográficos
Autores principales:	González-Ochoa, S., Tellez-Bañuelos, M. C., Méndez-Clemente, A. S., Bravo-Cuellar, A., Hernández Flores, G., Palafox-Mariscal, L. A., Haramati, J., Pedraza-Brindis, E. J., Sánchez-Reyes, K., Ortiz-Lazareno, P. C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020142/ https://www.ncbi.nlm.nih.gov/pubmed/35465350 http://dx.doi.org/10.1155/2022/1810804

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