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Transcutaneous auricular vagus nerve stimulation augments postprandial inhibition of ghrelin
Vagus nerve stimulation (VNS) facilitates weight loss in animals and patients treated with VNS for depression or epilepsy. Likewise, chronic transcutaneous auricular VNS (taVNS) reduces weight gain and improves glucose tolerance in Zucker diabetic fatty rats. If these metabolic effects of taVNS obse...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020171/ https://www.ncbi.nlm.nih.gov/pubmed/35441808 http://dx.doi.org/10.14814/phy2.15253 |
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author | Kozorosky, Erica M. Lee, Cristina H. Lee, Jessica G. Nunez Martinez, Valeria Padayachee, Leandra E. Stauss, Harald M. |
author_facet | Kozorosky, Erica M. Lee, Cristina H. Lee, Jessica G. Nunez Martinez, Valeria Padayachee, Leandra E. Stauss, Harald M. |
author_sort | Kozorosky, Erica M. |
collection | PubMed |
description | Vagus nerve stimulation (VNS) facilitates weight loss in animals and patients treated with VNS for depression or epilepsy. Likewise, chronic transcutaneous auricular VNS (taVNS) reduces weight gain and improves glucose tolerance in Zucker diabetic fatty rats. If these metabolic effects of taVNS observed in rats translate to humans is unknown. Therefore, the hypothesis of this study was that acute application of taVNS affects glucotropic and orexigenic hormones which could potentially facilitate weight loss and improve glucose tolerance if taVNS were applied chronically. In two single‐blinded randomized cross‐over protocols, blood glucose levels, plasma concentrations of insulin, C‐peptide, glucagon, leptin, and ghrelin, together with heart rate variability and baroreceptor‐heart rate reflex sensitivity were determined before and after taVNS (left ear, 10 Hz, 300 µs, 2.0–2.5 mA, 30 min) or sham‐taVNS (electrode attached to ear with the stimulator turned off). In a first protocol, subjects (n = 16) were fasted throughout the protocol and in a second protocol, subjects (n = 10) received a high‐calorie beverage (220 kCal) after the first blood sample, just before initiation of taVNS or sham‐taVNS. No significant effects of taVNS on heart rate variability and baroreceptor‐heart rate reflex sensitivity and only minor effects on glucotropic hormones were observed. However, in the second protocol taVNS significantly lowered postprandial plasma ghrelin levels (taVNS: −115.5 ± 28.3 pg/ml vs. sham‐taVNS: −51.2 ± 30.6 pg/ml, p < 0.05). This finding provides a rationale for follow‐up studies testing the hypothesis that chronic application of taVNS may reduce food intake through inhibition of ghrelin and, therefore, may indirectly improve glucose tolerance through weight loss. |
format | Online Article Text |
id | pubmed-9020171 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90201712022-04-25 Transcutaneous auricular vagus nerve stimulation augments postprandial inhibition of ghrelin Kozorosky, Erica M. Lee, Cristina H. Lee, Jessica G. Nunez Martinez, Valeria Padayachee, Leandra E. Stauss, Harald M. Physiol Rep Original Articles Vagus nerve stimulation (VNS) facilitates weight loss in animals and patients treated with VNS for depression or epilepsy. Likewise, chronic transcutaneous auricular VNS (taVNS) reduces weight gain and improves glucose tolerance in Zucker diabetic fatty rats. If these metabolic effects of taVNS observed in rats translate to humans is unknown. Therefore, the hypothesis of this study was that acute application of taVNS affects glucotropic and orexigenic hormones which could potentially facilitate weight loss and improve glucose tolerance if taVNS were applied chronically. In two single‐blinded randomized cross‐over protocols, blood glucose levels, plasma concentrations of insulin, C‐peptide, glucagon, leptin, and ghrelin, together with heart rate variability and baroreceptor‐heart rate reflex sensitivity were determined before and after taVNS (left ear, 10 Hz, 300 µs, 2.0–2.5 mA, 30 min) or sham‐taVNS (electrode attached to ear with the stimulator turned off). In a first protocol, subjects (n = 16) were fasted throughout the protocol and in a second protocol, subjects (n = 10) received a high‐calorie beverage (220 kCal) after the first blood sample, just before initiation of taVNS or sham‐taVNS. No significant effects of taVNS on heart rate variability and baroreceptor‐heart rate reflex sensitivity and only minor effects on glucotropic hormones were observed. However, in the second protocol taVNS significantly lowered postprandial plasma ghrelin levels (taVNS: −115.5 ± 28.3 pg/ml vs. sham‐taVNS: −51.2 ± 30.6 pg/ml, p < 0.05). This finding provides a rationale for follow‐up studies testing the hypothesis that chronic application of taVNS may reduce food intake through inhibition of ghrelin and, therefore, may indirectly improve glucose tolerance through weight loss. John Wiley and Sons Inc. 2022-04-20 /pmc/articles/PMC9020171/ /pubmed/35441808 http://dx.doi.org/10.14814/phy2.15253 Text en © 2022 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Kozorosky, Erica M. Lee, Cristina H. Lee, Jessica G. Nunez Martinez, Valeria Padayachee, Leandra E. Stauss, Harald M. Transcutaneous auricular vagus nerve stimulation augments postprandial inhibition of ghrelin |
title | Transcutaneous auricular vagus nerve stimulation augments postprandial inhibition of ghrelin |
title_full | Transcutaneous auricular vagus nerve stimulation augments postprandial inhibition of ghrelin |
title_fullStr | Transcutaneous auricular vagus nerve stimulation augments postprandial inhibition of ghrelin |
title_full_unstemmed | Transcutaneous auricular vagus nerve stimulation augments postprandial inhibition of ghrelin |
title_short | Transcutaneous auricular vagus nerve stimulation augments postprandial inhibition of ghrelin |
title_sort | transcutaneous auricular vagus nerve stimulation augments postprandial inhibition of ghrelin |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020171/ https://www.ncbi.nlm.nih.gov/pubmed/35441808 http://dx.doi.org/10.14814/phy2.15253 |
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