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Direct observation of protein structural transitions through entire amyloid aggregation processes in water using 2D-IR spectroscopy

Amyloid proteins that undergo self-assembly to form insoluble fibrillar aggregates have attracted much attention due to their role in biological and pathological significance in amyloidosis. This study aims to understand the amyloid aggregation dynamics of insulin (INS) in H(2)O using two-dimensiona...

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Detalles Bibliográficos
Autores principales: Chun, So Yeon, Son, Myung Kook, Park, Chae Ri, Lim, Chaiho, Kim, Hugh I., Kwak, Kyungwon, Cho, Minhaeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020176/
https://www.ncbi.nlm.nih.gov/pubmed/35656138
http://dx.doi.org/10.1039/d1sc06047c

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