Cargando…

Association of serum osteopontin with first hospitalization and all-cause mortality after kidney transplantation

OBJECTIVE: Osteopontin (OPN) is involved in vascular calcification and atherosclerosis. We evaluated the association between serum OPN levels and the first postoperative hospitalization and all-cause mortality in patients who received kidney transplantation (KT). MATERIALS AND METHODS: Seventy KT re...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Hsiao-Hui, Hsu, Bang-Gee, Ho, Ching-Chun, Lee, Ming-Che
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020252/
https://www.ncbi.nlm.nih.gov/pubmed/35465290
http://dx.doi.org/10.4103/tcmj.tcmj_269_20
_version_ 1784689498263650304
author Yang, Hsiao-Hui
Hsu, Bang-Gee
Ho, Ching-Chun
Lee, Ming-Che
author_facet Yang, Hsiao-Hui
Hsu, Bang-Gee
Ho, Ching-Chun
Lee, Ming-Che
author_sort Yang, Hsiao-Hui
collection PubMed
description OBJECTIVE: Osteopontin (OPN) is involved in vascular calcification and atherosclerosis. We evaluated the association between serum OPN levels and the first postoperative hospitalization and all-cause mortality in patients who received kidney transplantation (KT). MATERIALS AND METHODS: Seventy KT recipients were enrolled in this study from January to April 2012. The primary end point was first postoperative hospitalization or death. All patients were monitored in the outpatient clinics until June 30, 2017. Serum OPN level was measured by enzyme-linked immunosorbent assay. RESULTS: During follow-up (median length, 65 months), 47 first postoperative hospitalizations and 8 deaths occurred. In comparison with serum median OPN levels, serum OPN level was positively associated with KT duration (P = 0.048), serum blood urea nitrogen (BUN; P = 0.043), and serum creatinine levels (P = 0.045) but negatively associated with estimated glomerular filtration rate (eGFR; P = 0.049). Hospitalized KT recipients had a higher prevalence of diabetes mellitus (DM) (P = 0.032), BUN (P = 0.002), and serum OPN level (P = 0.001) but lower eGFR (P = 0.030) than did patients not hospitalized. KT recipients who died had higher serum level of creatinine (P = 0.009) and OPN (P = 0.001) but lower eGFR (P = 0.036) than did surviving patients. Multivariate Cox analysis adjusted for age, gender, DM, hypertension, eGFR, KT duration, and steroid used showed that serum OPN level was associated with both first postoperative hospitalization (P = 0.049) and all-cause mortality (P = 0.017). CONCLUSIONS: Serum OPN level is a potential biomarker for first postoperative hospitalization and all-cause mortality in KT recipients.
format Online
Article
Text
id pubmed-9020252
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-90202522022-04-21 Association of serum osteopontin with first hospitalization and all-cause mortality after kidney transplantation Yang, Hsiao-Hui Hsu, Bang-Gee Ho, Ching-Chun Lee, Ming-Che Tzu Chi Med J Original Article OBJECTIVE: Osteopontin (OPN) is involved in vascular calcification and atherosclerosis. We evaluated the association between serum OPN levels and the first postoperative hospitalization and all-cause mortality in patients who received kidney transplantation (KT). MATERIALS AND METHODS: Seventy KT recipients were enrolled in this study from January to April 2012. The primary end point was first postoperative hospitalization or death. All patients were monitored in the outpatient clinics until June 30, 2017. Serum OPN level was measured by enzyme-linked immunosorbent assay. RESULTS: During follow-up (median length, 65 months), 47 first postoperative hospitalizations and 8 deaths occurred. In comparison with serum median OPN levels, serum OPN level was positively associated with KT duration (P = 0.048), serum blood urea nitrogen (BUN; P = 0.043), and serum creatinine levels (P = 0.045) but negatively associated with estimated glomerular filtration rate (eGFR; P = 0.049). Hospitalized KT recipients had a higher prevalence of diabetes mellitus (DM) (P = 0.032), BUN (P = 0.002), and serum OPN level (P = 0.001) but lower eGFR (P = 0.030) than did patients not hospitalized. KT recipients who died had higher serum level of creatinine (P = 0.009) and OPN (P = 0.001) but lower eGFR (P = 0.036) than did surviving patients. Multivariate Cox analysis adjusted for age, gender, DM, hypertension, eGFR, KT duration, and steroid used showed that serum OPN level was associated with both first postoperative hospitalization (P = 0.049) and all-cause mortality (P = 0.017). CONCLUSIONS: Serum OPN level is a potential biomarker for first postoperative hospitalization and all-cause mortality in KT recipients. Wolters Kluwer - Medknow 2021-04-01 /pmc/articles/PMC9020252/ /pubmed/35465290 http://dx.doi.org/10.4103/tcmj.tcmj_269_20 Text en Copyright: © 2021 Tzu Chi Medical Journal https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Yang, Hsiao-Hui
Hsu, Bang-Gee
Ho, Ching-Chun
Lee, Ming-Che
Association of serum osteopontin with first hospitalization and all-cause mortality after kidney transplantation
title Association of serum osteopontin with first hospitalization and all-cause mortality after kidney transplantation
title_full Association of serum osteopontin with first hospitalization and all-cause mortality after kidney transplantation
title_fullStr Association of serum osteopontin with first hospitalization and all-cause mortality after kidney transplantation
title_full_unstemmed Association of serum osteopontin with first hospitalization and all-cause mortality after kidney transplantation
title_short Association of serum osteopontin with first hospitalization and all-cause mortality after kidney transplantation
title_sort association of serum osteopontin with first hospitalization and all-cause mortality after kidney transplantation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020252/
https://www.ncbi.nlm.nih.gov/pubmed/35465290
http://dx.doi.org/10.4103/tcmj.tcmj_269_20
work_keys_str_mv AT yanghsiaohui associationofserumosteopontinwithfirsthospitalizationandallcausemortalityafterkidneytransplantation
AT hsubanggee associationofserumosteopontinwithfirsthospitalizationandallcausemortalityafterkidneytransplantation
AT hochingchun associationofserumosteopontinwithfirsthospitalizationandallcausemortalityafterkidneytransplantation
AT leemingche associationofserumosteopontinwithfirsthospitalizationandallcausemortalityafterkidneytransplantation