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Association of serum osteopontin with first hospitalization and all-cause mortality after kidney transplantation
OBJECTIVE: Osteopontin (OPN) is involved in vascular calcification and atherosclerosis. We evaluated the association between serum OPN levels and the first postoperative hospitalization and all-cause mortality in patients who received kidney transplantation (KT). MATERIALS AND METHODS: Seventy KT re...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020252/ https://www.ncbi.nlm.nih.gov/pubmed/35465290 http://dx.doi.org/10.4103/tcmj.tcmj_269_20 |
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author | Yang, Hsiao-Hui Hsu, Bang-Gee Ho, Ching-Chun Lee, Ming-Che |
author_facet | Yang, Hsiao-Hui Hsu, Bang-Gee Ho, Ching-Chun Lee, Ming-Che |
author_sort | Yang, Hsiao-Hui |
collection | PubMed |
description | OBJECTIVE: Osteopontin (OPN) is involved in vascular calcification and atherosclerosis. We evaluated the association between serum OPN levels and the first postoperative hospitalization and all-cause mortality in patients who received kidney transplantation (KT). MATERIALS AND METHODS: Seventy KT recipients were enrolled in this study from January to April 2012. The primary end point was first postoperative hospitalization or death. All patients were monitored in the outpatient clinics until June 30, 2017. Serum OPN level was measured by enzyme-linked immunosorbent assay. RESULTS: During follow-up (median length, 65 months), 47 first postoperative hospitalizations and 8 deaths occurred. In comparison with serum median OPN levels, serum OPN level was positively associated with KT duration (P = 0.048), serum blood urea nitrogen (BUN; P = 0.043), and serum creatinine levels (P = 0.045) but negatively associated with estimated glomerular filtration rate (eGFR; P = 0.049). Hospitalized KT recipients had a higher prevalence of diabetes mellitus (DM) (P = 0.032), BUN (P = 0.002), and serum OPN level (P = 0.001) but lower eGFR (P = 0.030) than did patients not hospitalized. KT recipients who died had higher serum level of creatinine (P = 0.009) and OPN (P = 0.001) but lower eGFR (P = 0.036) than did surviving patients. Multivariate Cox analysis adjusted for age, gender, DM, hypertension, eGFR, KT duration, and steroid used showed that serum OPN level was associated with both first postoperative hospitalization (P = 0.049) and all-cause mortality (P = 0.017). CONCLUSIONS: Serum OPN level is a potential biomarker for first postoperative hospitalization and all-cause mortality in KT recipients. |
format | Online Article Text |
id | pubmed-9020252 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-90202522022-04-21 Association of serum osteopontin with first hospitalization and all-cause mortality after kidney transplantation Yang, Hsiao-Hui Hsu, Bang-Gee Ho, Ching-Chun Lee, Ming-Che Tzu Chi Med J Original Article OBJECTIVE: Osteopontin (OPN) is involved in vascular calcification and atherosclerosis. We evaluated the association between serum OPN levels and the first postoperative hospitalization and all-cause mortality in patients who received kidney transplantation (KT). MATERIALS AND METHODS: Seventy KT recipients were enrolled in this study from January to April 2012. The primary end point was first postoperative hospitalization or death. All patients were monitored in the outpatient clinics until June 30, 2017. Serum OPN level was measured by enzyme-linked immunosorbent assay. RESULTS: During follow-up (median length, 65 months), 47 first postoperative hospitalizations and 8 deaths occurred. In comparison with serum median OPN levels, serum OPN level was positively associated with KT duration (P = 0.048), serum blood urea nitrogen (BUN; P = 0.043), and serum creatinine levels (P = 0.045) but negatively associated with estimated glomerular filtration rate (eGFR; P = 0.049). Hospitalized KT recipients had a higher prevalence of diabetes mellitus (DM) (P = 0.032), BUN (P = 0.002), and serum OPN level (P = 0.001) but lower eGFR (P = 0.030) than did patients not hospitalized. KT recipients who died had higher serum level of creatinine (P = 0.009) and OPN (P = 0.001) but lower eGFR (P = 0.036) than did surviving patients. Multivariate Cox analysis adjusted for age, gender, DM, hypertension, eGFR, KT duration, and steroid used showed that serum OPN level was associated with both first postoperative hospitalization (P = 0.049) and all-cause mortality (P = 0.017). CONCLUSIONS: Serum OPN level is a potential biomarker for first postoperative hospitalization and all-cause mortality in KT recipients. Wolters Kluwer - Medknow 2021-04-01 /pmc/articles/PMC9020252/ /pubmed/35465290 http://dx.doi.org/10.4103/tcmj.tcmj_269_20 Text en Copyright: © 2021 Tzu Chi Medical Journal https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Yang, Hsiao-Hui Hsu, Bang-Gee Ho, Ching-Chun Lee, Ming-Che Association of serum osteopontin with first hospitalization and all-cause mortality after kidney transplantation |
title | Association of serum osteopontin with first hospitalization and all-cause mortality after kidney transplantation |
title_full | Association of serum osteopontin with first hospitalization and all-cause mortality after kidney transplantation |
title_fullStr | Association of serum osteopontin with first hospitalization and all-cause mortality after kidney transplantation |
title_full_unstemmed | Association of serum osteopontin with first hospitalization and all-cause mortality after kidney transplantation |
title_short | Association of serum osteopontin with first hospitalization and all-cause mortality after kidney transplantation |
title_sort | association of serum osteopontin with first hospitalization and all-cause mortality after kidney transplantation |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020252/ https://www.ncbi.nlm.nih.gov/pubmed/35465290 http://dx.doi.org/10.4103/tcmj.tcmj_269_20 |
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