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Osteocalcin and the physiology of danger

Bone biology has long been driven by the question as to what molecules affect cell differentiation or the functions of bone. Exploring this issue has been an extraordinarily powerful way to improve our knowledge of bone development and physiology. More recently, a second question has emerged: does b...

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Detalles Bibliográficos
Autores principales: Berger, Julian Meyer, Karsenty, Gerard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020278/
https://www.ncbi.nlm.nih.gov/pubmed/34913486
http://dx.doi.org/10.1002/1873-3468.14259
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author Berger, Julian Meyer
Karsenty, Gerard
author_facet Berger, Julian Meyer
Karsenty, Gerard
author_sort Berger, Julian Meyer
collection PubMed
description Bone biology has long been driven by the question as to what molecules affect cell differentiation or the functions of bone. Exploring this issue has been an extraordinarily powerful way to improve our knowledge of bone development and physiology. More recently, a second question has emerged: does bone have other functions besides making bone? Addressing this conundrum revealed that the bone-derived hormone osteocalcin affects a surprisingly large number of organs and physiological processes, including acute stress response. This review will focus on this emerging aspect of bone biology taking osteocalcin as a case study and will show how classical and endocrine functions of bone help to define a new functional identity for this tissue.
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spelling pubmed-90202782022-04-20 Osteocalcin and the physiology of danger Berger, Julian Meyer Karsenty, Gerard FEBS Lett Article Bone biology has long been driven by the question as to what molecules affect cell differentiation or the functions of bone. Exploring this issue has been an extraordinarily powerful way to improve our knowledge of bone development and physiology. More recently, a second question has emerged: does bone have other functions besides making bone? Addressing this conundrum revealed that the bone-derived hormone osteocalcin affects a surprisingly large number of organs and physiological processes, including acute stress response. This review will focus on this emerging aspect of bone biology taking osteocalcin as a case study and will show how classical and endocrine functions of bone help to define a new functional identity for this tissue. 2022-03 2022-01-21 /pmc/articles/PMC9020278/ /pubmed/34913486 http://dx.doi.org/10.1002/1873-3468.14259 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Article
Berger, Julian Meyer
Karsenty, Gerard
Osteocalcin and the physiology of danger
title Osteocalcin and the physiology of danger
title_full Osteocalcin and the physiology of danger
title_fullStr Osteocalcin and the physiology of danger
title_full_unstemmed Osteocalcin and the physiology of danger
title_short Osteocalcin and the physiology of danger
title_sort osteocalcin and the physiology of danger
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020278/
https://www.ncbi.nlm.nih.gov/pubmed/34913486
http://dx.doi.org/10.1002/1873-3468.14259
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